Pharmacological effects and bio-active compounds of Plantago major


Baimakhanova B. Sadanov A. Orasymbet S. Amangeldi A. Smirnova I. Baimakhanova G. Trenozhnikova L. Ratnikova I. Assilbayeva J. Toxanbayeva Z. Ibragimova A. Zhumalina K. Anarbayeva R. Asylova N. Nurgaliyeva Z. Turgumbayeva A.
April-June 2025Grupo de Investigacion en Atencion Farmaceutica

Pharmacy Practice
2025#23Issue 2

The purpose of this review is to provide a comprehensive overview of the research conducted on the chemical constituents and biological characteristics of Plantago major, Plantaginaceae. Methods: A comprehensive search of scientific databases, including Google, Google Scholar, PubMed, Science Direct, Researchgate and other online collections were extensively utilized. For efficient re-trieval, specific keywords like “Plantaginaceae”, “Plantago major bio-active compounds ”, “Plantago major. phyto-chemicals”, “Plantago major L. pharmacological activities”, and “Plantago major’’ traditional uses”. Results: The medicinal benefits of herbal plants are recognized worldwide, and numerous scientific studies have been conducted to validate their effectiveness. Additionally, the emergence of drug-resistant microorganisms in recent years has prompted researchers to investigate the effects of medicinal plants on these pathogens. Plantago major one a such plant the healing properties have been acknowledged worldwide for numerous years. This particular plant contains various potent chemical compounds, including alkaloids, terpenoids, flavonoids, fatty acids, polysaccharides, vitamins, phenolic acid derivatives, and iridoid glycosides. These constituents contribute to its therapeutic effects and its wide range of medicinal qualities, such as antioxidant, antibacterial, anti-inflammatory, anti-diabetic, anti-cancer, and anti-ulcer properties. The main objective of this review is to highlight the potential use of Plantago major extracts as herbal remedies and explore their extensive therapeutic capabilities. Conclusion: Plantago major plays a significant role in the treatment of various diseases and specific health conditions, including diarrhoea, ulcers, bacterial infections, inflammation, and cancer. Research has demonstrated that this plant contains multiple classes of essential bioactive compounds, such as alkaloids, flavonoids, fatty acids, vitamins, iridoid glycosides, terpenoids, and phenolic compounds like caffeic acid. The therapeutic properties and biological activity of Plantago major are largely attributed to these active chemical components. However, further research is needed to fully understand the precise mechanisms and activities of the primary bioactive compounds responsible for treating specific diseases.

antibacterial , antioxidant , bio-active compounds , Plantago major; phytoconstitution

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Research and Production Center for Microbiology and Virology, Almaty, Kazakhstan
Department of microbial preparations, Research and Production Center for Microbiology and Virology, Almaty, Kazakhstan
Department of Ecological and Agricultural Microbiology, Research and Production Center for Microbiology and Virology, Almaty, Kazakhstan
Department of food microbiology, Research and Production Center for Microbiology and Virology, Almaty, Kazakhstan
Department of Pharmaceutical Disciplines, Astana Medical University, Astana, Kazakhstan
Department «Pharmacology, Pharmacotherapy and Clinical Pharmacology», South Kazakhstan Medical Academy, Shymkent, Kazakhstan
Department of Pharmacology, Pharmacotherapy and Clinical Pharmacology, South Kazakhstan Medical Academy, Shymkent, Kazakhstan
Department of Pharmacy, Kazakh-Russian Medical University, Almaty, Kazakhstan
Department of Drug Technology, South Kazakhstan Medical Academy, Shymkent, Kazakhstan
School of Pediatrics, S.D. Asfendiyarov Kazakh National Medical University, Almaty, Kazakhstan
Department of Fundamental Medicine, al-Farabi Kazakh National University, Almaty, Kazakhstan

Research and Production Center for Microbiology and Virology
Department of microbial preparations
Department of Ecological and Agricultural Microbiology
Department of food microbiology
Department of Pharmaceutical Disciplines
Department «Pharmacology
Department of Pharmacology
Department of Pharmacy
Department of Drug Technology
School of Pediatrics
Department of Fundamental Medicine

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