Role of Base Excision Repair Pathway in the Processing of Complex DNA Damage Generated by Oxidative Stress and Anticancer Drugs

Baiken Y. Kanayeva D. Taipakova S. Groisman R. Ishchenko A.A. Begimbetova D. Matkarimov B. Saparbaev M.
22 January 2021 Frontiers Media S.A.

Frontiers in Cell and Developmental Biology
2021 #8

Chemical alterations in DNA induced by genotoxic factors can have a complex nature such as bulky DNA adducts, interstrand DNA cross-links (ICLs), and clustered DNA lesions (including double-strand breaks, DSB). Complex DNA damage (CDD) has a complex character/structure as compared to singular lesions like randomly distributed abasic sites, deaminated, alkylated, and oxidized DNA bases. CDD is thought to be critical since they are more challenging to repair than singular lesions. Although CDD naturally constitutes a relatively minor fraction of the overall DNA damage induced by free radicals, DNA cross-linking agents, and ionizing radiation, if left unrepaired, these lesions cause a number of serious consequences, such as gross chromosomal rearrangements and genome instability. If not tightly controlled, the repair of ICLs and clustered bi-stranded oxidized bases via DNA excision repair will either inhibit initial steps of repair or produce persistent chromosomal breaks and consequently be lethal for the cells. Biochemical and genetic evidences indicate that the removal of CDD requires concurrent involvement of a number of distinct DNA repair pathways including poly(ADP-ribose) polymerase (PARP)-mediated DNA strand break repair, base excision repair (BER), nucleotide incision repair (NIR), global genome and transcription coupled nucleotide excision repair (GG-NER and TC-NER, respectively), mismatch repair (MMR), homologous recombination (HR), non-homologous end joining (NHEJ), and translesion DNA synthesis (TLS) pathways. In this review, we describe the role of DNA glycosylase-mediated BER pathway in the removal of complex DNA lesions. © Copyright

base excision repair , bulky DNA adduct , DNA glycosylase , Fanconi anemia , inter-strand DNA crosslink , nucleotide excision repair

Text of the article Перейти на текст статьи

School of Sciences and Humanities, Nazarbayev University, Nur-Sultan, Kazakhstan
National Laboratory Astana, Nazarbayev University, Nur-Sultan, Kazakhstan
School of Engineering and Digital Sciences, Nazarbayev University, Nur-Sultan, Kazakhstan
Department of Molecular Biology and Genetics, Faculty of Biology and Biotechnology, al-Farabi, Kazakh National University, Almaty, Kazakhstan
Groupe ≪, Mechanisms of DNA Repair and Carcinogenesis≫, Equipe Labellisée LIGUE 2016, CNRS UMR9019, Université Paris-Saclay, Gustave Roussy Cancer Campus, Villejuif, France

School of Sciences and Humanities
National Laboratory Astana
School of Engineering and Digital Sciences
Department of Molecular Biology and Genetics
Groupe ≪

10 лет помогаем публиковать статьи Международный издатель

Книга Публикация научной статьи Волощук 2026 Book Publication of a scientific article 2026