Elevated Levels of Plasma Collagen Triple Helix Repeat Containing 1 (CTHRC1) Are Strongly Associated with eGFR and Albuminuria in Chronic Kidney Disease

Baiken Y. Markhametova Z. Ashimova A. Zhulamanova A. Nogaibayeva A. Kozina L. Matkarimov B. Aituov B. Gaipov A. Myngbay A.
April 2023 MDPI

Medicina (Lithuania)
2023 #59 Issue 4

Background: Chronic kidney disease (CKD) has various etiologies, making it impossible to fully understand its complex pathophysiology. Elevated levels of plasma creatinine, proteinuria, and albuminuria and declined eGFR are traits observed in CKD patients. The current study attempts to highlight the collagen triple helix repeat containing 1 (CTHRC1) protein as a putative blood biomarker for CKD in addition to existing recognized indicators of CKD progression. Methods: A total of 26 CKD patients and 18 healthy controls were enrolled in this study. Clinical characteristics and complete blood and biochemical analyses were collected, and human ELISA kits were used to detect possible CKD biomarkers. Results: The study’s findings showed that CTHRC1 correlates with key clinical markers of kidney function such as 24 h urine total protein, creatinine, urea, and uric acid. In addition, CTHRC1 demonstrated a strong significant difference (p ≤ 0.0001) between the CKD and control group. Conclusions: Our research demonstrates that the plasma level of CTHRC1 can distinguish between those with CKD and healthy patients. Plasma CTHRC1 levels may aid in the diagnosis of CKD given the current state of knowledge, and these results call for further investigation in a wider, more diverse patient group.

chronic kidney disease , CKD , CTHRC1 , glomerulonephritis , kidney disease

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School of Engineering and Digital Sciences, Nazarbayev University, Astana, 010000, Kazakhstan
PI National Laboratory Astana, Nazarbayev University, Astana, 010000, Kazakhstan
School of Sciences and Humanities, Nazarbayev University, Astana, 010000, Kazakhstan
Department of Medicine, Nazarbayev University School of Medicine, Astana, 020000, Kazakhstan
Department of Education, LLP BBNura, Astana, 010000, Kazakhstan
Department of Laboratory Diagnostics, National Scientific Medical Center, Astana, 010000, Kazakhstan
Center for BioEnergy Research LLP, Astana, 010000, Kazakhstan
Clinical Academic Department of Internal Medicine, CF “University Medical Center”, Astana, 010000, Kazakhstan

School of Engineering and Digital Sciences
PI National Laboratory Astana
School of Sciences and Humanities
Department of Medicine
Department of Education
Department of Laboratory Diagnostics
Center for BioEnergy Research LLP
Clinical Academic Department of Internal Medicine

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