Application of Biocomposite Hydrogel With Developed Trabecular Cage in Lumbar Interbody Fusion: A Clinical Case Report
Baidarbekov M.U. Bekarisov O.S. Ipmagambetov Z.N. Abdigalikov M.S. Akimbekov A.A.
January-December 2025SAGE Publications Ltd
Clinical Medicine Insights: Case Reports
2025#18
Background: Lumbar interbody fusion (LIF) is a widely used surgical technique for treating degenerative spinal conditions. However, challenges such as pseudarthrosis and implant migration remain significant concerns. This case report presents the use of a novel trabecular titanium cage combined with a biocomposite hydrogel containing stromal-vascular fraction and BMP-2 to enhance osseointegration and accelerate bone fusion. Case presentation: A 61-year-old female patient with severe chronic lumbar pain, functional impairment, and grade II anterolisthesis of L4 underwent lumbar interbody fusion. A custom-designed trabecular titanium cage was implanted, featuring an optimized porous structure for enhanced fixation and bone ingrowth. To further promote bone regeneration, a biocomposite hydrogel synthesized from adipose-derived stromal-vascular fraction and BMP-2 was applied. Postoperative assessment demonstrated significant pain reduction, improved functional activity, and early bone fusion formation. Radiological imaging confirmed stable implant positioning, progressive trabecularization, and successful osseointegration. No complications, such as implant migration or material loosening, were observed. Conclusions: This case highlights the potential benefits of combining advanced implant design with bioactive materials in spinal fusion surgery. The approach resulted in early and stable bone integration, reduced pain, and improved functional recovery. Further studies with larger patient cohorts and extended follow-up periods are needed to validate these findings and assess long-term outcomes.
biocomposite hydrogel , bone regeneration , lumbar interbody fusion , spinal surgery , trabecular titanium cage
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National Scientific Center of Traumatology and Orthopedics Named After Academician N.D. Batpenov, Astana, Kazakhstan
Medical University of Karaganda, Karaganda, Kazakhstan
National Research Oncology Center, Astana, Kazakhstan
National Scientific Center of Traumatology and Orthopedics Named After Academician N.D. Batpenov
Medical University of Karaganda
National Research Oncology Center
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