Prevalence of high-risk human papillomavirus infection among Kazakhstani women attending gynecological outpatient clinics
Babi A. Issa T. Issanov A. Akilzhanova A. Nurgaliyeva K. Abugalieva Z. Ukybassova T. Daribay Z. Khan S.A. Chan C.K. Azizan A. Aimagambetova G.
August 2021Elsevier B.V.
International Journal of Infectious Diseases
2021#1098 - 16 pp.
Objectives: To conduct a nationwide high-risk human papillomavirus (HR-HPV) infection genotyping analysis of women attending gynecological clinics and identify factors associated with HR-HPV infection. Methods: A cross-sectional survey-based study with 759 participants. Demographics, lifestyle, and medical history data were collected by questionnaire completed by gynecologists during patients’ visits. Cervical swabs were used for HPV genotyping using AmpliSens kit. Data analysis included descriptive statistics consisting of mean values, standard deviations, and frequencies, where applicable. Ordinal logistic regression was performed to identify factors associated with HPV infection status. Results: The mean age of participants was 36.51 ± 10.09 years. The majority of participants were aged 26–35 years. Less than half of the women (39%) were HPV positive; 26% had single HR-HPV, and 13% had multiple HR-HPV infection. The most prevalent HR-HPV genotypes were HPV-16 (54%), HPV-51 (7%), HPV-68 (7%), and HPV-18 (6%). Ordinal logistic regression demonstrated that older age, not being single, and having a history of sexually transmitted infections, decrease the odds of HPV infection. Conclusion: This study identified high prevalence of HR-HPV among Kazakhstani women. Our results showed that adding HPV testing to compulsory cervical cancer screening in Kazakhstan could improve the screening program and decrease cervical cancer rates.
Cervical cancer , Cervical intraepithelial neoplasia , High-risk HPV , HPV , HPV epidemiology , Kazakhstan
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Department of Biomedical Sciences, School of Medicine, Nazarbayev University, Nur-Sultan, 010000, Kazakhstan
Department of Medicine, School of Medicine, Nazarbayev University, Nur-Sultan, 010000, Kazakhstan
Laboratory of Genomic and Personalized Medicine, Center for Life Sciences, National Laboratory Astana, Nazarbayev University, Nur-Sultan, 010000, Kazakhstan
Republican Diagnostic Center, University Medical Center, Nur-Sultan, 010000, Kazakhstan
Clinical Academic Department of Womens Health, University Medical Center, Nur-Sultan, 010000, Kazakhstan
Department of Obstetrics and Gynecology #2, Marat Ospanov West Kazakhstan State Medical University, Aktobe, 030000, Kazakhstan
Regional Perinatal Center, Aktobe, 030000, Kazakhstan
Department of Microbiology and Molecular Genetics, School of Medicine, University of Pittsburgh, Pittsburgh, 15261, PA, United States
Department of Biology, College of Science and Technology, Wenzhou-Kean University, Wenzhou, 325060, China
College of Osteopathic Medicine, Touro University Nevada, Henderson, 89014, NV, United States
Department of Biomedical Sciences
Department of Medicine
Laboratory of Genomic and Personalized Medicine
Republican Diagnostic Center
Clinical Academic Department of Womens Health
Department of Obstetrics and Gynecology #2
Regional Perinatal Center
Department of Microbiology and Molecular Genetics
Department of Biology
College of Osteopathic Medicine
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