Impact of Appendectomy on Gut Microbiota
Babakhanov A.T. Dzhumabekov A.T. Zhao A.V. Kuandykov Y.K. Tanabayeva S.B. Fakhradiyev I.R. Nazarenko Y. Saliev T.M.
1 September 2021Mary Ann Liebert Inc.
Surgical Infections
2021#22Issue 7651 - 661 pp.
Background: Considered vestigial from the classic point of view, the vermiform appendix has long been the subject of intensive studies. The recent understanding of appendix function in the context of unique architecture and bacterial complexity and density allows considering it as a safehouse for intestinal biodiversity. Methods: This review analyzes and assesses the current state of scientific knowledge regarding the role of the vermiform appendix in normal gut microbiota maintenance as a crucial factor of host homeostasis. It also highlights the difference in microbial composition between the large bowel and the appendix, as well as the association between the surgical excision, appendectomy, and dysbiosis-induced diseases. In addition, the review discusses the results of epidemiologic studies on appendectomy as a risk factor for the initiation of gastrointestinal carcinogenesis. It also highlights the association between appendectomy and a series of chronic inflammatory and neurologic disorders, including inflammatory bowel disease. Copyright
appendectomy , appendicitis , dysbiosis , gut microbiome , microbiology
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Central City Clinical Hospital No. 12, Almaty, Kazakhstan
Kazakh Medical University of Continuing Education, Almaty, Kazakhstan
Institute of Surgery named after A.V. Vishnevsky, Moscow, Russian Federation
Khoja Akhmet Yassawi International Kazakh-Turkish University, Shymkent Medical Institute Postgraduate Studies Faculty, Shymkent, Kazakhstan
S.D. Asfendiyarov Kazakh National Medical University, Almaty, Kazakhstan
Central City Clinical Hospital No. 12
Kazakh Medical University of Continuing Education
Institute of Surgery named after A.V. Vishnevsky
Khoja Akhmet Yassawi International Kazakh-Turkish University
S.D. Asfendiyarov Kazakh National Medical University
10 лет помогаем публиковать статьи Международный издатель
Книга Публикация научной статьи Волощук 2026 Book Publication of a scientific article 2026