Multi-Amine Decorated with Gold Nanoparticles Supported on Multi-Walled Carbon Nanotubes (CNT-CPTMS-PEHA-Au) as Novel Nanocomposites for Investigation of Photothermal Chemotherapy
Azimkhanova B. Hassan E.F. Shirshab S. Al-Hussainy A.F. Tuama S.J. Radhi F. Ahmed S. Hammady F.J. Farkhod A. Khurshida N. Ilhamberdi S. Khasan S. Diyorbek Y.
April 2025University of Kashan
Journal of Nanostructures
2025#15Issue 2788 - 800 pp.
In this study, a novel nanocomposite, CNT-CPTMS-PEHA-Au, was synthesized through a multi-step surface functionalization strategy aimed at enhancing photothermal chemotherapy efficacy. Multi-walled carbon nanotubes (MWCNTs) were first oxidized to introduce functional groups, followed by silanization with 3-chloropropyltrimethoxysilane (3-CPTMS) and subsequent attachment of pentaethylenehexamine (PEHA) to graft amino functionalities. Gold nanoparticles (AuNPs) were then uniformly deposited onto the functionalized CNT surface via in situ reduction of HAuCl4 with sodium borohydride, resulting in a stable nanocomposite exhibiting well-dispersed AuNPs approximately 40–50 nm in size. Characterization through FE-SEM and FT-IR confirmed the morphological integrity, successful surface modifications, and gold loading. The nanocomposite demonstrated rapid and stable in vitro photothermal conversion, reaching a maximum temperature of 47.8 °C within 10 minutes under 808 nm laser irradiation at 1.5 W/cm2, with excellent thermal stability over consecutive cycles. Biological evaluation using MCF-7 cells revealed significant temperature-dependent cytotoxicity, with up to 67% cell death at 50 μg/mL post-irradiation. These results underscore the potential of CNT-CPTMS-PEHA-Au as an efficient, stable, and targeted platform for minimally invasive photothermal cancer therapy, while highlighting challenges related to in vivo translation and scalable synthesis. Future studies should focus on targeting specificity and biocompatibility enhancements for clinical viability.
Carbon nanotubes , Gold nanoparticles , Nanocomposites , Photothermal chemotherapy
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Department of Biochemistry, NCJSC Asfendiyarov Kazakh National Medical University, Almaty, Kazakhstan
Department of Clinical Pharmacy, College of Pharmacy, University of Al-Ameed, Karbala, Iraq
Warka University College, Iraq
College of Pharmacy, Ahl Al Bayt University, Kerbala, Iraq
College of Health and Medical Technologies, National University of Science and Technology, Dhi Qar, Iraq
Department of Dentistry, Al-Manara College for Medical Sciences, Maysan, Iraq
Department of Nursing, Al-Zahrawi University College, Karbala, Iraq
Mazaya University College, Iraq
Department of “Nuclear Medicine and Medical Radiology”, Bukhara State Medical Institute, Bukhara, Uzbekistan
Tashkent State Technical University named after Islam Karimov, Uzbekistan
Ferghana Medical Institute of Public Health, Uzbekistan
Department of Obstetrics-Gynecology №2, Samarkand State Medical University, Uzbekistan
Department of Fruits and Vegetables, Urganch State University, Uzbekistan
Department of Biochemistry
Department of Clinical Pharmacy
Warka University College
College of Pharmacy
College of Health and Medical Technologies
Department of Dentistry
Department of Nursing
Mazaya University College
Department of “Nuclear Medicine and Medical Radiology”
Tashkent State Technical University named after Islam Karimov
Ferghana Medical Institute of Public Health
Department of Obstetrics-Gynecology №2
Department of Fruits and Vegetables
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