Phytochemical Study of Achillea setacea Waldst. et Kit. with Anticholinesterase, Antidiabetic, Anti-Urease, and Anti-Tyrosinase Activities
Azhikhanova Z. Duru M.E. Megbenu H.K. Kucukaydin S. Tas-Kucukaydin M. Baisalova G. Shaimardan M. Seiilgazy M. Adekenov S. Nuraje N. Özler M.A.
October 2024Engineered Science Publisher
Engineered Science
2024#31
This study focuses on the phytochemical composition and different biological activities of A setacea Waldst. et Kit, a wild species indigenous to the Ortau Mountain in the Karaganda region of the Republic of Kazakhstan. Utilizing the ultrasound-assisted extraction method, we evaluated the extraction efficiency through phytochemical analysis. Phenolic compounds in the extract were identified and quantified using a high-performance liquid chromatograph coupled with a diode array detector (HPLC-DAD). The major phenolic compounds identified in the methanol extracts of Ach. setacea were chlorogenic acids, coumarins, ellagic acids and apigenin in flowers (17.48, 13.84, 7.87 and 55.47 µg/g, respectively), aerial parts (73.41, 18.20 and 10.25, 3.76 µg/g, respectively) and roots (14.79, 9.95 and 4.02 µg/g, respectively). In comparison with the underground portion of the plant extracts, flowers and aerial parts exhibited higher total phenolic and flavonoid contents. For instance, chlorogenic acid, coumarin, myricetin, quercetin, apigenin, and ellagic acid show higher amounts in the flower and the plants aerial part than the underground part. Furthermore, we found that hexane-based root extracts demonstrated superior cholinesterase and diabetic inhibitory activities compared to methanol extracts. On the contrary, methanol extracts exhibited higher uretic and tyrosinase inhibitory activities compared to those obtained from hexane extract.
Achillea setacea , Anti-tyrosinase activity , Anticholinesterase , Antidiabetic , Phenolic and flavonoid contents
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Department of Chemistry, L.N. Gumilyov Eurasian National University, Satpayev, Astana, 010000, Kazakhstan
Department of Chemistry, Faculty of Science, Muğla Sıtkı Koçman University, Kotekli, Muğla, 48000, Turkey
Department of Chemical and Materials Engineering, School of Engineering and Digital Science, Nazarbayev University, Kabanbay Batyr, Astana, 010000, Kazakhstan
Department of Medical Services and Techniques, Köyceğiz Vocational School of Health Services, Muğla Sıtkı Koçman University, Köyceğiz, Muğla, 48800, Turkey
Renewable Energy Laboratory, National Laboratory Astana, Nazarbayev University, Kabanbay Batyr, Astana, 010000, Kazakhstan
JSC International Research and Production Holding Phytochemistry, Gazaliyev, Karaganda, 100009, Kazakhstan
Department of Chemistry
Department of Chemistry
Department of Chemical and Materials Engineering
Department of Medical Services and Techniques
Renewable Energy Laboratory
JSC International Research and Production Holding Phytochemistry
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