Hemoadsorption in Children with Cytokine Storm Using the Jafron HA330 and HA380 Cartridges

Azenova K. Sazonov V.
September 2025 Multidisciplinary Digital Publishing Institute (MDPI)

Journal of Clinical Medicine
2025 #14 Issue 18

Background: A cytokine storm can lead to organ dysfunction and death in critically ill children. Extracorporeal hemoperfusion aims to reduce hyperinflammation by filtering out mid-range cytokines (e.g., IL-6), but pediatric data remain limited. Methods: We conducted a narrative review with PRISMA-guided screening of PubMed, Scopus, and Google Scholar for pediatric reports of HA330/HA380 from January 2020 to June 2025. Due to heterogeneity in populations, circuits, and outcome timing, the results were synthesized descriptively. Three studies met the inclusion criteria: a prospective series of 12 patients with septic shock using HA330, a single case of a pediatric heart transplant with HA380 during cardiopulmonary bypass, and a retrospective comparative cohort study of Pediatric Intensive Care Unit (PICU) oncology patients on continuous renal replacement therapy (CRRT) comparing HA330 (n = 11) versus CytoSorb (n = 10). Results: Three studies involving 23 pediatric patients were analyzed. The median age was 8 years, and 56.5% of patients were male. Most patients underwent hemoadsorption with HA330 via continuous renal replacement therapy (CRRT) or continuous venovenous hemodiafiltration (CVVHDF). Post-treatment reductions were noted in interleukin-6 (IL-6) (mean −69.6%), C-reactive protein (CRP) (−59.0%), and procalcitonin (PCT) (−70.4%). Severity scores (Pediatric Logistic Organ Dysfunction-2 (PELOD-2), Pediatric Risk of Mortality-3 (PRISM-3), and Pediatric Sequential Organ Failure Assessment (pSOFA) improved significantly (p = 0.002). The mean PICU stay was 15.6 days. The survival rate was 87%, and no hemoadsorption-related adverse events were reported. Conclusions: HA330/380 hemoadsorption is a safe and potentially effective treatment for pediatric cytokine storms, reducing inflammation and improving clinical status. However, larger, standardized studies are needed to confirm these findings and guide clinical use.

HA330/380 , hemadsorption , hemoperfusion , pediatric sepsis , sepsis

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Department of Medicine, School of Medicine, Nazarbayev University, Z05, Astana, K4F4, Kazakhstan
Department of Surgery, School of Medicine, Nazarbayev University, Astana, Z05K4F4, Kazakhstan
Pediatric Anesthesiology and Intensive Care Unit, National Research Center for Maternal and Child Health, University Medical Center, Astana, Z05K4F4, Kazakhstan

Department of Medicine
Department of Surgery
Pediatric Anesthesiology and Intensive Care Unit

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