Picomolar detection of thrombin with fiber-optic ball resonator sensor using optical backscatter reflectometry
Ayupova T. Shaimerdenova M. Sypabekova M. Vangelista L. Tosi D.
September 2021Elsevier GmbH
Optik
2021#241
A ball resonator, positioned on the tip of an optical fiber, has been developed as a biosensor for the prototypic detection of thrombin. The device was fabricated with a fast and repeatable CO2 laser splicing method, followed by gold-sputtering and functionalization for the measurement of various protein concentrations. The ball resonator acts as a weak interferometer with a return loss below − 50 dB, and it is interrogated with an optical backscatter reflectometer measuring the reflection spectrum. We report here a sample presenting high sensitivity (1273.74 nm/RIU, RIU = refractive index units), which allows protein detection in the range 0.4–100 pM, with a limit of detection of 1.56 pM in logarithmic response.
Aptamer , Biosensor , Optical backscatter reflectometry , Optical ball resonator , Optical fiber biosensor , Thrombin
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Nazarbayev University, School of Engineering and Digital Sciences, Nur-Sultan, 010000, Kazakhstan
Laboratory of Biosensors and Bioinstruments, National Laboratory Astana, Nur-Sultan, 010000, Kazakhstan
Nazarbayev University School of Medicine, Nur-Sultan, 010000, Kazakhstan
Nazarbayev University
Laboratory of Biosensors and Bioinstruments
Nazarbayev University School of Medicine
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