Regulatory role of circular RNAs in oral squamous cell carcinoma

Attar R. Noel K. Romero M.A. Sabitaliyevich U.Y. Yulaevna I.M. Qureshi M.Z.
2023 Cellular and Molecular Biology Association

Cellular and Molecular Biology
2023 #69 Issue 8 250 - 257 pp.

OSCC is a genomically complicated disease and advancements in the modern era of molecular oncology have enabled researchers to portray near-to-complete resolution of signaling landscape. Over the last two decades, overwhelming proof-of-concept has established mechanistic regulatory role of non-coding RNAs in carcinogenesis, including OSCC. Circular RNAs demonstrate a burgeoning facet of oncology research and molecular biologists are only beginning to appreciate and recognize the significance of circRNAs in the pathogenesis of OSCC. Regulatory roles of non-coding RNAs in the re-shaping of signaling pathways offer plausible strategies for prevention/inhibition of OSCC. Circular RNAs have mechanistic roles in OSCC and sponge effects mediated by a wider variety of circRNAs need to be rationally targeted for effective cancer prevention. Phenomenal and cutting-edge research works in different types of animal models will further refine our knowledge for selection of most promising circRNAs as pharmacologically valuable targets. Copyright:

Apoptosis , circular RNAs , Metastasis , non-coding RNAs , Oral Squamous cell carcinoma

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Department of Obstetrics and Gynecology, Yeditepe University Hospital, Istanbul, 34755, Turkey
Human Anatomy Department, College of Medicine, Al-Mustansiriyah University, Baghdad, Iraq
Facultad de Medicina, Universidad Autónoma de Guerrero, Laboratorio de Investigación Clínica, Av. Solidaridad S/N, Colonia Hornos Insurgentes, cp 39300, Acapulco, Mexico
Scientific Center for Innovative Technologies and Research, Kazakhstan
E. A. Buketov Karaganda University, Kazakhstan
Deanship of Educational Services, Department of Biochemistry, Qassim University, Buraydah, Al Qassim, Buraidah, 51452, Saudi Arabia

Department of Obstetrics and Gynecology
Human Anatomy Department
Facultad de Medicina
Scientific Center for Innovative Technologies and Research
E. A. Buketov Karaganda University
Deanship of Educational Services

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