Overview of the signaling pathways involved in metastasis: An intriguing story-tale of the metastatic journey of ovarian cancer cells
Attar R. Panah T. Romero M.A. Yulaevna I.M. Gazouli M. Berardi R. Wieczorek E. Farooqi A.A.
25 November 2021Cellular and Molecular Biology Association
Cellular and Molecular Biology
2021#67Issue 3212 - 223 pp.
Wealth of information has revolutionized our understanding related to the genetics and functional genomics of this heterogeneous disease. Keeping in view the heterogeneity of ovarian cancer, long-term survival might be achieved by translation of recently emerging mechanistic insights at the cellular and molecular levels to personalize individual strategies for treatment and to identify biomarkers for early detection. Importantly, the motility and invasive properties of ovarian cancer cells are driven by a repertoire of signaling cascades, many components of which have been experimentally verified as therapeutic targets in preclinical models as well as in clinical trials. Scientific evidence garnered over decades of research has deconvoluted the highly intricate intertwined network of intracellular signaling pathways which played fundamental role in carcinogenesis and metastasis. In this review we have provided a compendium of myriad of signaling cascades which have been documented to play critical role in the progression and metastasis of ovarian cancer. We have partitioned this multi-component review into different sections to individually discuss and summarize the roles of TGF/SMAD, JAK/STAT, Wnt/β-Catenin, NOTCH, SHH/GLI, mTORC1/ mTORC2, VEGFR and Hippo/YAP pathways in ovarian cancer metastasis. Copyright:
Apoptosis , Cancer , Pharmacology , Signaling , Therapy
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Department of Obstetrics and Gynecology, Yeditepe University, Turkey
Independent Research, Turkey
Facultad de Medicina, Universidad Autónoma de Guerrero, Laboratorio de Investigación Clínica, Av. Solidaridad S/N, Colonia Hornos Insurgentes, cp, Guerrero, Acapulco, 39300, Mexico
E. A. Buketov Karaganda University, Kazakhstan
Laboratory of Biology, Medical School, National and Kapodistrian University of Athens, Athens, 11527, Greece
Clinica Oncologica, Università Politecnica delle Marche - Azienda Ospedaliera Universitaria Ospedali Riuniti di Ancona, Ancona, Italy
Department of Translational Research, Nofer Institute of Occupational Medicine, Lodz, Poland
Institute of Biomedical and Genetic Engineering (IBGE), 24 Mauve Area, Sector G-9/1, Islamabad, 54000, Pakistan
Department of Obstetrics and Gynecology
Independent Research
Facultad de Medicina
E. A. Buketov Karaganda University
Laboratory of Biology
Clinica Oncologica
Department of Translational Research
Institute of Biomedical and Genetic Engineering (IBGE)
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