Mechanistic role of pyroptosis in tumor microenvironment and tumor immunotherapy
Attar R. Qureshi M.Z. Sabitaliyevich U.Y. Yulaevna I.M. Romero M.A.
28 April 2024Cellular and Molecular Biology Association
Cellular and Molecular Biology
2024#70Issue 4260 - 267 pp.
In recent decades, extraordinary attention has been devoted to cell death pathways principally because of multifaceted regulatory roles in normal developmental and pathophysiological processes. The removal of functionally defective, infected or potentially malignant cells is regulated by programmed cell death (PCD) cascades. Pyroptotic cell death is a highly complicated pro-inflammatory form of cell death. Pyroptosis is characterized by the formation of pores in the plasma membrane by oligomerization of the N-terminal fragment of gasdermins (gasdermin-NT) following the cleavage of gasdermin. Pyroptosis plays a pivotal role in the innate immune responses and mechanistically steered by inflammasome-mediated and inflammasome-independent cascades. In this review, we have comprehensively analyzed how different signaling pathways regulated pyroptosis in cancer inhibition and metastatic spread of cancer cells to the secondary sites. Comprehensive understanding of the interconnection between signaling pathways and pyroptosis will enable us to reap maximum benefits from the exciting mechanistic insights gained from pioneering studies related to pyroptosis.
Cancer , Cell Signaling , Metastasis , PD-L1/PD-1 signaling , Pyroptosis
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Department of Obstetrics and Gynecology, Yeditepe University Hospital, Istanbul, 34755, Turkey
Department of Environment and Natural Resources, College of Agriculture and Food, Qassim University, P.O. Box 6622, Buraidah, 51452, Saudi Arabia
Scientific Center for Innovative Technologies and Research, Kazakhstan
E. A. Buketov Karaganda University, Kazakhstan
Facultad de Medicina, Universidad Autónoma de Guerrero, Laboratorio de Investigación Clínica, Av. Solidaridad S/N, Colonia Hornos Insurgentes, cp 39300, Guerrero, Acapulco, Mexico
Department of Obstetrics and Gynecology
Department of Environment and Natural Resources
Scientific Center for Innovative Technologies and Research
E. A. Buketov Karaganda University
Facultad de Medicina
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