Biocompatible and low-cost iodine-doped carbon dots as a bifunctional fluorescent and radiocontrast agent for X-ray CT imaging
Atabaev T.S. Askar D. Baranchiyeva Z. Zhainsabayeva B.A. Elebessov T. Kang M.S. Duisenbayeva B. Mun E.A. Pham T.T. Han D.-W.
29 October 2024Royal Society of Chemistry
Materials Advances
2024#5Issue 229000 - 9006 pp.
Carbon dot-based radiocontrast agents have recently sparked the interest of researchers owing to their better contrasting capabilities, simple synthesis protocols, high colloidal stability, and good biocompatibility. In this study, we propose for the first time the synthesis of iodine-doped carbon dots (I-CDs) using low-cost reagents such as citric acid (C6H8O7), urea (CH4N2O) and potassium iodide (KI). The as-prepared I-CDs demonstrated excellent colloidal stability (with a zeta potential value of −64.7 mV), excitation-dependent fluorescent properties (with a maximum quantum yield of ∼8.9%), and a mean iodine concentration of ∼4.67 wt%. Notably, the as-prepared I-CDs displayed greater X-ray attenuation efficiency (42.87 HU mL mg−1) as compared to the commercially employed iopromide radiocontrast agent (30.98 HU mL mg−1). Furthermore, ATPase activity, cytotoxicity analysis with HeLa, NHDF, HEK293, and A549 cell lines, and live-cell imaging experiments of the Drosophila neuroblasts in intact brain lobes suggested high biocompatibility and nontoxicity of the prepared I-CDs. Overall, biocompatible and low-cost I-CDs show great promise as bifunctional radiocontrast and fluorescent agents for biomedical applications.
Text of the article Перейти на текст статьи
Department of Chemistry, Nazarbayev University, Astana, 010000, Kazakhstan
Department of Biology, Nazarbayev University, Astana, 010000, Kazakhstan
Department of Cogno-Mechatronics Engineering, Pusan National University, Busan, 46241, South Korea
Department of Radiology, Republican Diagnostic Center, Astana, 010000, Kazakhstan
Department of Chemistry
Department of Biology
Department of Cogno-Mechatronics Engineering
Department of Radiology
10 лет помогаем публиковать статьи Международный издатель
Книга Публикация научной статьи Волощук 2026 Book Publication of a scientific article 2026