Assessment of Short-Term Effects of Cell Transplantation in Cirrhosis DUE to HCV
Astrakhan A. Saparbaev S. Amanzholkyzy A. Iskakova A. Nurlanova G. Kurmangazin M.
2024Asian Pacific Organization for Cancer Prevention
Asian Pacific Journal of Cancer Prevention
2024#25Issue 62099 - 2104 pp.
Background and Objectives: Recent studies have highlighted the potential of fetal hepatic stem cells in regenerative treatments for liver diseases. This study aimed to evaluate the short-term effects of fetal stem cell transplantation in patients with liver cirrhosis resulting from chronic hepatitis C. Materials and Methods: Thirty patients with liver cirrhosis of all Child-Turcotte-Pugh classes due to chronic hepatitis C, aged 18 to 65 years, were selected for this study. A single intravenous dose of 1 ml containing 6*106 fetal hepatic stem cells, diluted in 20.0 ml of 0.9% sodium chloride solution, was administered. The efficacy of the treatment was assessed by measuring levels of ALT, AST, total and direct bilirubin, gamma-glutamyltranspeptidase, alkaline phosphatase, total protein, and albumin before and after cell therapy. Results: Post-treatment, a significant reduction was noted in the Child-Pugh score from 8 [6–9] to 7 [6–8] (p<0.001) and the MELD index from 11 [7–15] to 10 [7–14] (p=0.004). Skin itching decreased from 36.7% to 10%. Complaints of weakness increased significantly from 3.3% to 23.3% after 30 days of therapy (p=0.014), and the incidence of reduced appetite increased from 20% to 46.7% (p=0.021). No statistical differences were observed in the frequency of nosebleeds (86.7% initially vs. 90% at day 30, p=0.655) or drowsiness (63.3% initially vs. 76.7% at day 30, p=0.157). Significant reductions were noted in ALT levels by 35% and total bilirubin by 44%. The lack of significant changes in indicators of hepatic-cell insufficiency, particularly the protein-forming function as reflected in total protein and albumin levels, is likely due to the extent of liver tissue damage and thus a delayed recovery. Conclusion: The findings of this study affirm the clinical efficacy and promise of fetal hepatic stem cell therapy as part of a comprehensive treatment regimen for patients with liver cirrhosis.
Cell therapy , fetal stem cells , hepatitis C , liver cirrhosis
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West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan
West Kazakhstan Marat Ospanov Medical University
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Книга Публикация научной статьи Волощук 2026 Book Publication of a scientific article 2026