Synthesis of new generation amido-Phosphinite derivative complexes by microwave method and investigation of their biological activities
Assylbekova S. Meriç N. Kayan C. Şahin E. Zazybin A. Okumuş V. Zararsiz S.Ç. Durap F. Baysal A. Aydemir M.
1 January 2026Elsevier Ltd
Polyhedron
2026#283
Several biological activities such as antioxidant, antibacterial, and DNA binding of ruthenium, iridium, and rhodium complexes of a phosphinite were investigated. For this purpose, firstly, a new amide was synthesized from the reaction of 2-(phenylthio)aniline with DL-mandelic acid in a solvent-free environment using microwave irradiation. Subsequently, this amide was converted to its phosphinite counterpart. Then, Ru(II), Ir(III), and Rh(I) complexes (3–6) of the phosphinite were synthesized and characterized by several techniques such as microanalysis, IR, and NMR spectroscopy, and in the case of 4 by single crystal X-ray crystallography. Finally, antioxidant, antimicrobial, and DNA binding activities of [C20H16NOS{OPPh2-Ru(ηBergamini et al. (2004)6-p-cymene)Cl2}] (3), [C20H16NOS{OPPh2-Ru(ηBergamini et al. (2004)6-benzene)Cl2}] (4), [C20H16NOS{OPPh2-Ir(ηGaw et al. (2002)5-C5Me5)Cl2}] (5), and [C20H16NOS{OPPh2-Rh(cod)Cl}] (6) complexes were tested. To determine antioxidant activities of the complexes, DPPH (2,2-diphenyl-1-picryl hydrazyl) free radical scavenging, metal chelation, and reducing power activities were measured. At 200.0 mgL−1 concentration, complex 4 showed the highest radical scavenging (74.53 ± 1.76 %) and metal chelating activity (63.91 ± 1.54 %), while complex 3 exhibited the highest reducing power activity. Antibacterial activity of the compounds was determined with four pathogenic bacteria. Only ruthenium complexes 3 and 4 had weak activity against two Gram-positive bacteria, while the other complexes (5 and 6) did not show any antibacterial activity. Electrophoresis results using calf thymus DNA (CT-DNA) displayed that all complexes had DNA binding activity at different rates.
Biological activity , Iridium , Microwave , Phosphinite , Rhodium , Ruthenium , Solvent-free environment
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School of Chemical Engineering, Kazakh-British Technical University, Almaty, 050000, Kazakhstan
Department of Chemistry, Faculty of Science, University of Dicle, Diyarbakir, 21280, Turkey
Department of Hair Care and Beauty Services, Technical Vocational School, Dicle University, Diyarbakir, 21280, Turkey
Department of Chemistry, Faculty of Science, Atatürk University, Erzurum, 25240, Turkey
Department of Medical Biology, Faculty of Medicine, Siirt University, Siirt, 56100, Turkey
Department of Biology, of Natural and Applied Sciences, Siirt University, Siirt, 56100, Turkey
Science and Technology Application and Research Center (DUBTAM), Dicle University, Diyarbakir, 21280, Turkey
School of Chemical Engineering
Department of Chemistry
Department of Hair Care and Beauty Services
Department of Chemistry
Department of Medical Biology
Department of Biology
Science and Technology Application and Research Center (DUBTAM)
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