Kazak mitochondrial genomes provide insights into the human population history of Central Eurasia
Askapuli A. Vilar M. Garcia-Ortiz H. Zhabagin M. Sabitov Z. Akilzhanova A. Ramanculov E. Schamiloglu U. Martinez-Hernandez A. Contreras-Cubas C. Barajas-Olmos F. Schurr T.G. Zhumadilov Z. Flores-Huacuja M. Orozco L. Hawks J. Saitou N.
November 2022Public Library of Science
PLoS ONE
2022#17Issue 11 November
As a historical nomadic group in Central Asia, Kazaks have mainly inhabited the steppe zone from the Altay Mountains in the East to the Caspian Sea in the West. Fine scale characterization of the genetic profile and population structure of Kazaks would be invaluable for understanding their population history and modeling prehistoric human expansions across the Eurasian steppes. With this mind, we characterized the maternal lineages of 200 Kazaks from Jetisuu at mitochondrial genome level. Our results reveal that Jetisuu Kazaks have unique mtDNA haplotypes including those belonging to the basal branches of both West Eurasian (R0, H, HV) and East Eurasian (A, B, C, D) lineages. The great diversity observed in their maternal lineages may reflect pivotal geographic location of Kazaks in Eurasia and implies a complex history for this population. Comparative analyses of mitochondrial genomes of human populations in Central Eurasia reveal a common maternal genetic ancestry for Turko-Mongolian speakers and their expansion being responsible for the presence of East Eurasian maternal lineages in Central Eurasia. Our analyses further indicate maternal genetic affinity between the Sherpas from the Tibetan Plateau with the Turko-Mongolian speakers. Copyright:
Text of the article Перейти на текст статьи
School of Sciences and Humanities, Nazarbayev University, Astana, Kazakhstan
National Center for Biotechnology, Astana, Kazakhstan
National Laboratory Astana, Nazarbayev University, Astana, Kazakhstan
Department of Integrative Biology, University of Wisconsin-Madison, Madison, WI, United States
The Genographic Project, National Geographic Society, Washington, DC, United States
Department of Anthropology, University of Maryland, College Park, MD, United States
Immunogenomics and Metabolic Diseases Laboratory, National Institute of Genomic Medicine, Mexico City, Mexico
L.N. Gumilyov Eurasian National University, Astana, Kazakhstan
Department of Anthropology, University of Pennsylvania, Philadelphia, PA, United States
School of Medicine, Nazarbayev University, Astana, Kazakhstan
Department of Anthropology, University of Wisconsin-Madison, Madison, WI, United States
Population Genetics Laboratory, National Institute of Genetics, Shizuoka, Mishima, Japan
Department of Biological Sciences, Graduate School of Science, University of Tokyo, Tokyo, Japan
Advanced Medical Research Center, Faculty of Medicine, University of the Ryukyus, Okinawa, Japan
School of Sciences and Humanities
National Center for Biotechnology
National Laboratory Astana
Department of Integrative Biology
The Genographic Project
Department of Anthropology
Immunogenomics and Metabolic Diseases Laboratory
L.N. Gumilyov Eurasian National University
Department of Anthropology
School of Medicine
Department of Anthropology
Population Genetics Laboratory
Department of Biological Sciences
Advanced Medical Research Center
10 лет помогаем публиковать статьи Международный издатель
Книга Публикация научной статьи Волощук 2026 Book Publication of a scientific article 2026