Green-Synthesized Silver Nanoparticle–Assisted Radiofrequency Ablation for Improved Thermal Treatment Distribution
Ashikbayeva Z. Aitkulov A. Atabaev T.Sh. Blanc W. Inglezakis V.J. Tosi D.
February-1 2022MDPI
Nanomaterials
2022#12Issue 3
Thermal ablation therapy is known as an advantageous alternative to surgery allowing the treatment of multiple tumors located in hard-to-reach locations or treating patients with medical conditions that are not compatible with surgery. Appropriate heat propagation and precise control over the heat propagation is considered a weak point of thermal ablation therapy. In this work, silver nanoparticles (AgNPs) are used to improve the heat propagation properties during the thermal ablation procedure. Green-synthesized silver nanoparticles offer several attractive features, such as excellent thermal conductivity, biocompatibility, and antimicrobial activity. A distributed multiplexed fiber optic sensing system is used to monitor precisely the temperature change during nanoparticle-assisted radiofrequency ablation. An array of six MgO-based nanoparticles doped optical fibers spliced to single-mode fibers allowed us to obtain the two-dimensional thermal maps in a real time employing optical backscattering reflectometry at 2 mm resolution and 120 sensing points. The silver nanoparticles at 5, 10, and 20 mg/mL were employed to investigate their heating effects at several positions on the tissue regarding the active electrode. In addition, the pristine tissue and tissue treated with agarose solution were also tested for reference purposes. The results demonstrated that silver nanoparticles could increase the temperature during thermal therapies by propagating the heat. The highest temperature increase was obtained for 5 mg/mL silver nanoparticles introduced to the area close to the electrode with a 102% increase of the ablated area compared to the pristine tissue.
Distributed temperature sensing , Green synthesis , Hyperthermia , Minimally invasive cancer care , Optical fiber , Radiofrequency ablation , Silver nanoparticles
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School of Engineering and Digital Sciences, Nazarbayev University, 53 Kabanbay Batyr Ave, Nur-Sultan, 010000, Kazakhstan
Department of Information Engineering, University of Padova, Via Gardenigo 6/A, Padova, 35131, Italy
Department of Chemistry, Nazarbayev University, 53 Kabanbay Batyr Ave, Nur-Sultan, 010000, Kazakhstan
Université Côte d’Azur, INPHYNI, UMR7010, CNRS, Parc Valrose, Nice, 06108, France
Department of Chemical and Process Engineering, University of Strathclyde, 75 Montrose St, Glasgow, G1 1XJ, United Kingdom
National Laboratory Astana, Nazarbayev University, 53 Kabanbay Batyr Ave., Nur-Sultan, 010000, Kazakhstan
School of Engineering and Digital Sciences
Department of Information Engineering
Department of Chemistry
Université Côte d’Azur
Department of Chemical and Process Engineering
National Laboratory Astana
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