Quercetin Impact in Pancreatic Cancer: An Overview on Its Therapeutic Effects
Asgharian P. Tazehkand A.P. Soofiyani S.R. Hosseini K. Martorell M. Tarhriz V. Ahangari H. Cruz-Martins N. Sharifi-Rad J. Almarhoon Z.M. Ydyrys A. Nurzhanyat A. Yessenbekova A. Cho W.C.
2021Hindawi Limited
Oxidative Medicine and Cellular Longevity
2021#2021
Pancreatic cancer (PC) is a lethal malignancy cancer, and its mortality rates have been increasing worldwide. Diagnosis of this cancer is complicated, as it does not often present symptoms, and most patients present an irremediable tumor having a 5-year survival rate after diagnosis. Regarding treatment, many concerns have also been raised, as most tumors are found at advanced stages. At present, anticancer compounds-rich foods have been utilized to control PC. Among such bioactive molecules, flavonoid compounds have shown excellent anticancer abilities, such as quercetin, which has been used as an adjunctive or alternative drug to PC treatment by inhibitory or stimulatory biological mechanisms including autophagy, apoptosis, cell growth reduction or inhibition, EMT, oxidative stress, and enhancing sensitivity to chemotherapy agents. The recognition that this natural product has beneficial effects on cancer treatment has boosted the researchers’ interest towards more extensive studies to use herbal medicine for anticancer purposes. In addition, due to the expensive cost and high rate of side effects of anticancer drugs, attempts have been made to use quercetin but also other flavonoids for preventing and treating PC. Based on related studies, it has been found that the quercetin compound has significant effect on cancerous cell lines as well as animal models. Therefore, it can be used as a supplementary drug to treat a variety of cancers, particularly pancreatic cancer. This review is aimed at discussing the therapeutic effects of quercetin by targeting the molecular signaling pathway and identifying antigrowth, cell proliferation, antioxidative stress, EMT, induction of apoptotic, and autophagic features. Copyright
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Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
Department of Pharmacognosy, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran
Department of Biochemistry and Clinical Laboratories, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
Clinical Research Development Unit of Sina Educational, Research and Treatment Center, Tabriz University of Medical Sciences, Tabriz, Iran
Molecular Medicine Research Center, Biomedicine Institute, Tabriz University of Medical Sciences, Tabriz, Iran
Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran
Department of Molecular Medicine, Faculty of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Iran
Department of Nutrition and Dietetics, Faculty of Pharmacy and Centre for Healthy Living, University of Concepción, Concepción, 4070386, Chile
Department of Food Science and Technology, Faculty of Nutrition and Food Science, Tabriz University of Medical Sciences, Tabriz, Iran
Department of Biomedicine, Faculty of Medicine, University of Porto, Alameda Prof. Hernâni Monteiro, Porto, Portugal
Institute for Research and Innovation in Health (i3S), University of Porto, Porto, Portugal
Institute of Research and Advanced Training in Health Sciences and Technologies (CESPU), Rua Central de Gandra, 1317, Gandra PRD, 4585-116, Portugal
Facultad de Medicina, Universidad del Azuay, Cuenca, Ecuador
Department of Chemistry, College of Science, King Saud University, P. O. Box 2455, Riyadh, 11451, Saudi Arabia
Biomedical Research Centre, Al-Farabi Kazakh National University, Al-Farabi Av. 71, Almaty, 050040, Kazakhstan
Department of Biophysics, Biomedicine and Neuroscience, Al-Farabi Kazakh National University, Al-Farabi Av. 71, Almaty, 050040, Kazakhstan
Department of Clinical Oncology, Queen Elizabeth Hospital, Kowloon, Hong Kong
Drug Applied Research Center
Department of Pharmacognosy
Department of Biochemistry and Clinical Laboratories
Clinical Research Development Unit of Sina Educational
Molecular Medicine Research Center
Student Research Committee
Department of Molecular Medicine
Department of Nutrition and Dietetics
Department of Food Science and Technology
Department of Biomedicine
Institute for Research and Innovation in Health (i3S)
Institute of Research and Advanced Training in Health Sciences and Technologies (CESPU)
Facultad de Medicina
Department of Chemistry
Biomedical Research Centre
Department of Biophysics
Department of Clinical Oncology
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