Health and Treatment-Related Anxiety among Kidney Transplant Recipients in Kazakhstan
Asanova A. Bolatov A. Suleimenova D. Khazhgaliyeva Y. Pya Y.
2025National Scientific Medical Center
Journal of Clinical Medicine of Kazakhstan
2025#22Issue 420 - 28 pp.
Background: Kidney transplantation (KTx) is a life-saving intervention, but post-transplant psychological well-being and treatment adherence remain critical challenges. This study aimed to (1) develop and validate a Health and Treatment-Related Anxiety Scale in Kazakh and Russian languages, (2) identify predictors of such anxiety, and (3) examine its impact on adherence to treatment and well-being among kidney transplant recipients in Kazakhstan. Methods: A cross-sectional study was conducted among 223 adult kidney transplant recipients. The newly developed anxiety scale was tested for psychometric validity using exploratory and confirmatory factor analyses. Internal consistency and criterion-related validity were assessed through item-rest correlations and correlation with related outcomes. Multiple linear regression and mediation models were used to identify predictors of health and treatment-related anxiety and psychological mechanisms affecting treatment adherence and well-being. Results: The scale demonstrated strong psychometric properties with a one-factor structure and high internal consistency (Cronbach’s α=0.893). Anxiety negatively correlated with both treatment adherence (p<0.001). Regression analysis identified employment under disability status and perceived availability of post-KTx monitoring as protective factors. Emotional support and anxiety levels significantly predicted treatment adherence. Mediation analyses revealed that anxiety partially mediated the relationship between perceived post-KTx monitoring and both adherence and well-being (p<0.05). Conclusion: The validated anxiety scale is a reliable tool for assessing psychological vulnerability in kidney transplant recipients. Addressing treatment-related anxiety may enhance post-transplant care by improving both adherence and emotional well-being.
adherence , anxiety , kidney transplantation , validation , well-being
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Department of Science, “University Medical Center” Corporate Fund, Astana, Kazakhstan
School of Medicine, Shenzhen University, Shenzhen, China
School of Medicine, Nazarbayev University, Astana, Kazakhstan
Clinical Academic Department of Cardiac Surgery, “University Medical Center” Corporate Fund, Astana, Kazakhstan
Department of Science
School of Medicine
School of Medicine
Clinical Academic Department of Cardiac Surgery
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