Real-world data on managing patients with coronary artery disease and multifocal atherosclerosis. Results of the 12-month international clinical registry of patients with identified multifocal atherosclerosis in the Russian Federation and Eurasian countries (KAMMA)

Arutyunov G.P. Tarlovskaya E.I. Arutyunov A.G. Batluk T.I. Koziolova N.A. Chesnikova A.I. Vaskin A.Y. Tokmin D.S. Bakulin I.G. Barbarash O.L. Grigoryeva N.U. Gubareva I.V. Izmozherova N.V. Kamilova U.K. Kechedzhieva S.G. Kim Z.F. Koriagina N.A. Mironova S.V. Mitkovskaya N.P. Nemirova S.V. Nurieva L.M. Petrova M.M. Polyanskaya E.A. Rebrov A.P. Svarovskaya A.V. Smirnova E.A. Sugraliev A.B. Khovaeva Y.B. Shavkuta G.V. Shaposhnik I.I. Aimakhanova G.T. Alieva M.Y. Almukhanova A.B. Aparkina A.V. Akhmentaeva D.A. Bashkinov R.A. Bekisheva N.M. Belousova L.N. Blokhina E.I. Bochkareva V.O. Buianova M.V. Valikulova F.Y. Vende A.D. Galyavich A.S. Genkel V.V. Gorbunova E.V. Gordeychuk E.D. Grigorenko E.A. Grigoryeva E.V. Dabylova G.M. Davydkin I.L. Evdokimov D.S. Ermilova A.N. Zhangelova S.B. Zhdankina N.V. Zheleznyak E.I. Ilyanok N.S. Kapsultanova D.A. Karoli N.A. Kartashova E.A. Kuznetsova A.S. Kumaritova A.T. Magdeeva N.A. Makarov S.A. Mamadaliev O.A. Melnikov E.S. Musrepov N.J. Namatova R.Ya. Novikova M.V. Obukhova I.A. Ponomarenko E.V. Rubanenko A.O. Rubanenko O.A. Safronenko V.A. Suchkova E.I. Sycheva A.I. Tagaeva D.R. Trubnikova M.A. Trunina T.P. Tynalieva S.A. Frolov A.G. Khatlamadzhiyan V.V. Khokhlova Y.I. Chernyavina A.I. Chizhova O.Y. Shambatov M.A. Shnyukova T.V. Shchukin Y.V.
2025 Silicea-Poligraf

Russian Journal of Cardiology
2025 #30 Issue 3 7 - 17 pp.

Aim. To study real-world data on managing patients with coronary artery disease (CAD) and multifocal atherosclerosis (MFA) for 12 months by outpatient cardiologists. Material and methods. KAMMA is a real-world registry organized by the Eurasian Association of Therapists. The main branch included men and women over 18 years of age with confirmed atherosclerosis in two or more arterial systems and one or more risk factors for atherosclerosis. The start date for patient recruitment was February 1, 2022 and the end date was November 27, 2022. The design included 3 following visits: 1 — baseline, 2 — after 6 months, 3 — after 12 months. Twenty-eight research centers were located in 7 federal districts of the Russian Federation, as well as in the Republics of Kazakhstan, Uzbekistan and Belarus. Results. A patient population (n=2905) was formed, all of whom had verified CAD. The mean age was 66,0 [59,0; 72,0] years (men — 60,3%). Low-density lipoprotein cholesterol decreased by 20,4% over 12 months, while non-high-density lipoprotein cholesterol — by 12,7%. Over 12 months, lipid-lowering therapy did not undergo significant changes. Statin monotherapy was maintained in 83%, of which only 53,7% of patients received high-dose therapy. Combined statin+ezetimibe therapy was used in 12,4%, while statin+ezetimibe+PCSK9 inhibitor — in 4,6%. During the 1-year follow-up, antithrombotic therapy was not enhanced. Low prescription rate of combination therapy with antiplatelet agents (15,7%) and low-dose rivaroxaban and acetylsalicylic acid (7,9%) remained. By the follow-up end, a high incidence of major adverse cardiovascular events (8,8%) was registered in patients included in the KAMMA registry. Conclusion. Despite the fact that patients with MFA have a very high cardiovascular risk, routine management of these patients is characterized by high clinical inertia. During the 1-year follow-up, lipid-lowering and antithrombotic therapy was not properly strengthened, due to which the target levels of key lipid profile parameters were not achieved and a high rate of major adverse cardiovascular events was observed in patients included in the registry.

coronary artery disease , KAMMA registry , lipid-lowering therapy , multifocal atherosclerosis

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Association Eurasian Association of Internal Medicine, Moscow, Russian Federation
Piro-gov Russian National Research Medical University, Moscow, Russian Federation
Privolzhsky Research Medical University, Nizhny Novgorod, Russian Federation
S. Avdalbekyan National Institute of Health, Yerevan, Armenia
E. A. Wagner Perm State Medical University, Perm, Russian Federation
Rostov State Medical University, Rostov-on-Don, Russian Federation
Alpha-stat analytic agency, Moscow, Russian Federation
I. I. Mechnicov North-Western State Medical University, St. Petersburg, Russian Federation
Scientific Research Institute for Complex issues of cardiovascular disease, Kemerovo, Russian Federation
Lobachevsky National Research Nizhny Novgorod State University, Nizhny Novgorod, Russian Federation
Samara State Medical University, Samara, Russian Federation
Ural State Medical University, Yeka-terinburg, Russian Federation
Republican Specialized Scientific and Practical Medical Center of Therapy and Medical Rehabilitation, Tashkent, Uzbekistan
Stavro-pol State Medical University, Stavropol, Russian Federation
Kazan State Medical University, Kazan, Russian Federation
Sadykov City Clinical Hospital № 7, Kazan, Russian Federation
LLC Womens Health Clinic, Perm, Russian Federation
Perm Regional Hospital for Veterans War, Perm, Russian Federation
Republican Scientific and Practical Center Cardiology, Minsk, Belarus
V. F. Voino-Yasenetsky Krasnoyarsk State Medical University, Krasnoyarsk, Russian Federation
V. I. Razumovskiy Saratov State Medical University, Saratov, Russian Federation
Regio-nal Clinical Hospital, Saratov, Russian Federation
Cardiology Research Institute, Tomsk, Russian Federation
Tomsk National Research Medical Center, Tomsk, Russian Federation
Pavlov Ryazan State Medical University, Ryazan, Russian Federation
Asfendiyarov Kazakh National Medical University, Almaty, Kazakhstan
F. C. Gral City Clinical Hospital № 2, Perm, Russian Federation
South-Ural State Medical University, Chelyabinsk, Russian Federation
Clinical Rheumatology Hospital № 25, St. Petersburg, Russian Federation
City Polyclinic № 31 of Sovetsky District, Nizhny Novgorod, Russian Federation
L. S. Barbarash Kuzbass Clinical Cardiology Dispensary, Kemerovo, Russian Federation
Fomins clinic Michurinsky, Moscow, Russian Federation
Fomins clinic Dolgorukovskaya, Moscow, Russian Federation
Stavropol Regional Cardiology Dispensary, Stavropol, Russian Federation
LLC Health Formula, Krasnodar, Russian Federation
LLC Dr. Fomins clinic, Sochi, Russian Federation
City Clinical Hospital № 11, Ryazan, Russian Federation

Association Eurasian Association of Internal Medicine
Piro-gov Russian National Research Medical University
Privolzhsky Research Medical University
S. Avdalbekyan National Institute of Health
E. A. Wagner Perm State Medical University
Rostov State Medical University
Alpha-stat analytic agency
I. I. Mechnicov North-Western State Medical University
Scientific Research Institute for Complex issues of cardiovascular disease
Lobachevsky National Research Nizhny Novgorod State University
Samara State Medical University
Ural State Medical University
Republican Specialized Scientific and Practical Medical Center of Therapy and Medical Rehabilitation
Stavro-pol State Medical University
Kazan State Medical University
Sadykov City Clinical Hospital № 7
LLC Womens Health Clinic
Perm Regional Hospital for Veterans War
Republican Scientific and Practical Center Cardiology
V. F. Voino-Yasenetsky Krasnoyarsk State Medical University
V. I. Razumovskiy Saratov State Medical University
Regio-nal Clinical Hospital
Cardiology Research Institute
Tomsk National Research Medical Center
Pavlov Ryazan State Medical University
Asfendiyarov Kazakh National Medical University
F. C. Gral City Clinical Hospital № 2
South-Ural State Medical University
Clinical Rheumatology Hospital № 25
City Polyclinic № 31 of Sovetsky District
L. S. Barbarash Kuzbass Clinical Cardiology Dispensary
Fomins clinic Michurinsky
Fomins clinic Dolgorukovskaya
Stavropol Regional Cardiology Dispensary
LLC Health Formula
LLC Dr. Fomins clinic
City Clinical Hospital № 11

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