Peculiarities of polyvascular disease and the diagnostic significance of the ankle-brachial index in patients with coronary artery disease: results from the real-world registry KAMMA (Clinical registry on patient population with polyvascular disease in the Russian Federation and Eurasian countries)

Arutyunov G.P. Tarlovskaya E.I. Arutyunov A.G. Batluk T.I. Koziolova N.A. Chesnikova A.I. Vaskin A.Y. Tokmin D.S. Bakulin I.G. Barbarash O.L. Grigoryeva N.U. Gubareva I.V. Izmozherova N.V. Kamilova U.K. Kechedzhieva S.G. Kim Z.F. Koriagina N.A. Mironova S.V. Mitkovskaya N.P. Nemirova S.V. Nurieva L.M. Petrova M.M. Polyanskaya E.A. Rebrov A.P. Svarovskaya A.V. Smirnova E.A. Sugraliev A.B. Khovaeva Y.B. Shavkuta G.V. Shaposhnik I.I. Alieva M.Y. Almukhanova A.B. Aparkina A.V. Bashkinov R.A. Belousova L.N. Blokhina E.I. Bochkareva V.O. Buianova M.V. Valikulova F.Y. Vende A.D. Galyavich A.S. Genkel V.V. Gorbunova E.V. Gordeychuk E.D. Grigorenko E.A. Grigoryeva E.V. Davydkin I.L. Evdokimov D.S. Ermilova A.N. Zhangelova S.B. Zhdankina N.V. Zheleznyak E.I. Ilyanok N.S. Kapsultanova D.A. Karoli N.A. Kartashova E.A. Kuznetsova A.S. Kumaritova A.T. Magdeeva N.A. Makarov S.A. Melnikov E.S. Novikova M.V. Obukhova I.A. Ponomarenko E.V. Rubanenko A.O. Rubanenko O.A. Rustamova F.E. Safronenko V.A. Suchkova E.I. Sycheva A.I. Tagaeva D.R. Trubnikova M.A. Trunina T.P. Frolov A.G. Khatlamadzhiyan V.V. Khokhlova Y.I. Chernyavina A.I. Chizhova O.Y. Shambatov M.A. Shnyukova T.V. Shchukin Y.V.
2024 Silicea-Poligraf

Russian Journal of Cardiology
2024 #29 Issue 4 10 - 20 pp.

Aim. To investigate the prevalence and characteristics of polyvascular disease in the Eurasian regions population with one or more previously established locations of atherosclerotic arterial damage, and to evaluate the diagnostic importance of the ankle-brachial index (ABI) as a marker for polyvascular disease (PVD). Material and methods. A total of 1837 patients were included in the main branch of the KAMMA registry (patients with PVD), among which 91,6% had coronary artery disease (CAD) (n=1683). For further analysis, the group of patients with CAD was combined with 1222 patients included in the second branch of the registry — KAMMA-cardio, forming a patient population (n=2905), in which all patients had verified CAD. The mean age of patients was 66,0 [59,0; 72,0] years, with 60,3% being male. Peripheral arteries was assessed using ultrasound examination. Results. PVD was present in 95,6% of patients with coronary atherosclerosis: dual-region involvement was observed in 51,3% of patients, three-region involvement in 37,1%, four-region involvement in 3,4%, and five-region involvement in 2,0%. Stenoses of the common carotid artery were observed in 71% of patients, internal carotid artery — in 68%, lower limb artery — in 52%, and renal and mesenteric artery — in 8,3%. There were following diagnostic effectiveness of the ABI for detecting patients with lower limb artery stenosis was: sensitivity — 58,0%, specificity — 83,6%. The quality of antithrombotic and lipid-lowering therapy was insufficient. Conclusion. In the overwhelming majority (95,6%) of patients with CAD in the KAMMA registry, PVD was revealed, with nearly half of the patients having involvement in three or more arterial zones. In the patient population with CAD, there should be an active effort to identify patients with PVD, using at least the ABI determination and active modern antithrombotic and lipid-lowering therapy according to current clinical guidelines.

ankle-brachial index , coronary artery disease , multifocal atherosclerosis , polyvascular disease

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Eurasian Association of Internal Medicine, Moscow, Russian Federation
Pirogov Russian National Research Medical University, Moscow, Russian Federation
Privolzhsky Research Medical University, Nizhny Novgorod, Russian Federation
S. Avdalbekyan National Institute of Health, Yerevan, Armenia
E. A. Wagner Perm State Medical University, Perm, Russian Federation
Rostov State Medical University, Rostov-on-Don, Russian Federation
Alphastat Analytics Agency, Angarsk, Russian Federation
I. I. Mechnicov North-Western State Medical University, Saint-Petersburg, Russian Federation
Research Institute for Complex Issues of Cardiovascular Diseases, Kemerovo, Russian Federation
Lobachevsky National Research University, Nizhny Novgorod, Russian Federation
Samara State Medical University, Samara, Russian Federation
Ural State Medical University, Yekaterinburg, Russian Federation
Republican Specialized Scientific and Practical Medical Center of Therapy and Medical Rehabilitation, Tashkent, Uzbekistan
Stavropol State Medical University, Stavropol, Russian Federation
Kazan State Medical University, Kazan, Russian Federation
City Clinical Hospital № 7, Kazan, Russian Federation
LLC Womens Health Clinic, Perm, Russian Federation
Perm Regional Hospital for Veterans War, Perm, Russian Federation
Republican Scientific and Practical Center of Cardiology, Minsk, Belarus
N. S. Karpovich Krasnoyarsk Interdistrict Clinical Emergency Hospital, Krasnoyarsk, Russian Federation
V. I. Razu movskiy Saratov State Medical University, Saratov, Russian Federation
Regional Clinical Hos pital, Saratov, Russian Federation
Cardiology Research Institute, Tomsk, Russian Federation
Tomsk National Research Medical Center, Tomsk, Russian Federation
I. P. Pavlov Ryazan State Medical University, Ryazan, Russian Federation
Asfendiyarov Kazakh National Medical University, Almaty, Kazakhstan
F. C. Gral City Clinical Hospital № 2, Perm, Russian Federation
South-Ural State Medical University, Chelyabinsk, Russian Federation
Clinical Rheumatology Hospital № 25, Saint-Petersburg, Russian Federation
City Polyclinic № 31 of Sovetsky District, Nizhny Novgorod, Russian Federation
L. S. Barbarash Kuzbass Clinical Cardiology Dispensary, Kemerovo, Russian Federation
Fomins Сlinic Michurinsky, Moscow, Russian Federation
Fomins Сlinic Dolgorukovskaya, Moscow, Russian Federation
Stavropol Regional Cardiology Center, Stavropol, Russian Federation
Health Formula, Krasnodar, Russian Federation
Dr. Fomins Clinic, Sochi, Russian Federation
City Clinical Hospital № 11, Ryazan, Russian Federation

Eurasian Association of Internal Medicine
Pirogov Russian National Research Medical University
Privolzhsky Research Medical University
S. Avdalbekyan National Institute of Health
E. A. Wagner Perm State Medical University
Rostov State Medical University
Alphastat Analytics Agency
I. I. Mechnicov North-Western State Medical University
Research Institute for Complex Issues of Cardiovascular Diseases
Lobachevsky National Research University
Samara State Medical University
Ural State Medical University
Republican Specialized Scientific and Practical Medical Center of Therapy and Medical Rehabilitation
Stavropol State Medical University
Kazan State Medical University
City Clinical Hospital № 7
LLC Womens Health Clinic
Perm Regional Hospital for Veterans War
Republican Scientific and Practical Center of Cardiology
N. S. Karpovich Krasnoyarsk Interdistrict Clinical Emergency Hospital
V. I. Razu movskiy Saratov State Medical University
Regional Clinical Hos pital
Cardiology Research Institute
Tomsk National Research Medical Center
I. P. Pavlov Ryazan State Medical University
Asfendiyarov Kazakh National Medical University
F. C. Gral City Clinical Hospital № 2
South-Ural State Medical University
Clinical Rheumatology Hospital № 25
City Polyclinic № 31 of Sovetsky District
L. S. Barbarash Kuzbass Clinical Cardiology Dispensary
Fomins Сlinic Michurinsky
Fomins Сlinic Dolgorukovskaya
Stavropol Regional Cardiology Center
Health Formula
Dr. Fomins Clinic
City Clinical Hospital № 11

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