Lipid profile in hospitalized patients with covid-19 depending on the outcome of its acute phase: Data from the international registry dynamics analysis of comorbidities in SARS-CoV-2 infection survivors

Arutyunov G.P. Tarlovskaya E.I. Arutyunov A.G. Belenkov Yu.N. Konradi A.O. Lopatin Yu.M. Rebrov A.P. Tereshchenko S.N. Chesnikova A.I. Airapetyan G.G. Babin A.P. Bakulin I.G. Bakulina N.V. Balykova L.A. Blagonravova A.S. Boldina M.V. Butomo M.I. Vaisberg A.R. Galyavich A.S. Gomonova V.V. Grigorieva N.Yu. Gubareva I.V. Demko I.V. Evzerikhina A.V. Zharkov A.V. Zateyshchikova A.A. Kamilova U.K. Kim Z.F. Kuznetsova T.Yu. Kulikov A.N. Lareva N.V. Makarova E.V. Malchikova S.V. Nedogoda S.V. Petrova M.M. Pochinka I.G. Protasov K.V. Protsenko D.N. Ruzanov D.Yu. Saiganov S.A. Sarybaev A.Sh. Selezneva N.M. Sugraliev A.B. Fomin I.V. Khlynova O.V. Chizhova O.Yu. Shaposhnik I.I. Schukarev D.A. Abdrakhmanova A.K. Avetisyan S.A. Avoyan O.G. Azaryan K.K. Aimakhanova G.T. Aiypova D.A. Akunov A.Ch. Alieva M.K. Almukhambedova A.R. Aparkina A.V. Aruslanova O.R. Ashina E.Y. Badina O.Yu. Barysheva O.Yu. Batluk T.I. Batchaeva A.S. Bashkinov R.A. Bitieva A.M. Bikhteev I.U. Borodulina N.A. Bragin M.V. Brazhnik V.A. Budu A.M. Bykova G.A. Vagapova K.R. Varlamova D.D. Vezikova N.N. Verbitskaya E.A. Vilkova O.E. Vinnikova E.A. Vustina V.V. Galova E.A. Genkel V.V. Giller D.B. Gorshenina E.I. Grigoryeva E.V. Gubareva E.Y. Dabylova G.M. Demchenko A.I. Dolgikh O.Yu. Duishobaev M.Y. Evdokimov D.S. Egorova K.E. Ermilova A.N. Zheldybaeva A.E. Zarechnova N.V. Zimina Yu.D. Ivanova S.Yu. Ivanchenko E.Y. Ilyina M.V. Kazakovtseva M.V. Kazymova E.V. Kalinina Yu.S. Kamardina N.A. Karachenova A.M. Karetnikov I.A. Karoli N.A. Karsiev M.K. Kaskaeva D.S. Kasymova K.F. Kerimbekova J.B. Kim E.S. Kiseleva N.V. Klimenko D.A. Klimova A.V. Kovalishena O.V. Kozlov S.V. Kolmakova E.V. Kolchinskaya T.P. Kolyadich M.I. Kondryakova O.V. Konoval M.P. Konstantinov D.Yu. Konstantinova E.A. Kordyukova V.A. Koroleva E.V. Kraposhina A.Yu. Kryukova T.V. Kuznetsova A.P. Kuzmina T.Yu. Kuzmichev K.V. Kulchoroeva Ch.K. Kuprina T.V. Kuranova I.M. Kurenkova L.V. Kurchugina N.Yu. Kushubakova N.A. Levankova V.I. Ledyaeva A.A. Lisun T.V. Lisyanskaya V.E. Lyubavina N.A. Magdeeva N.A. Mazalov K.V. Mayseenko V.I. Makarova A.S. Maripov A.M. Markov N.V. Marusina A.A. Melnikov E.S. Metlinskaya A.I. Moiseenko N.B. Muradova F.N. Muradyan R.G. Musaelyan Sh.N. Nekaeva E.S. Nikitina N.M. Nifontov S.E. Obolentseva E.Yu. Obukhova A.A. Ogurlieva B.B. Odegova A.A. Omarova Y.U. Omurzakova N.A. Ospanova Sh.O. Pavlova V.A. Pakhomova E.V. Petrov L.D. Plastinina S.S. Platonov D.A. Pogrebetskaya V.A. Polyakov D.V. Polyakov D.S. Ponomarenko E.V. Popova L.L. Potanin A.A. Prokofieva N.A. Rabik Y.U. Rakov N.A. Rakhimov A.N. Rozanova N.A. Serikbolkyzy S. Sidorkina Ya.A. Simonov A.A. Skachkova V.V. Skvortsova R.D. Skuridin D.S. Solovieva D.V. Solovieva I.A. Sukhomlinova I.M. Sushilova A.G. Tagaeva D.R. Titoikina Y.U. Tikhonova E.P. Tokmin D.S. Tolmacheva A.A. Torgunakova M.S. Trenogina K.V. Trostyanetskaya N.A. Trofimov D.A. Trubnikova M.A. Tulichev A.A. Tursunova A.T. Ulanova N.D. Fatenkov O.V. Fedorishina O.V. Fil T.S. Fomina I.Yu. Fominova I.S. Frolova I.A. Tsvinger S.M. Tsoma V.V. Cholponbaeva M.B. Chudinovskikh T.I. Shavrin I.V. Shevchenko O.A. Shikhaliev D.R. Shishkina E.A. Shishkov K.Yu. Shcherbakov S.Yu. Shcherbakova G.V. Yausheva E.A.
2022 Silicea-Poligraf

Russian Journal of Cardiology
2022 #27 Issue 9 16 - 30 pp.

Aim. To study the lipid profile in hospitalized patients with coronavirus disease 2019 (COVID-19) depending on the outcome of its acute phase according to the AKTIV international registry. Material and methods. The AKTIV registry included men and women over 18 years of age with a diagnosis of COVID-19, who were treated in a hospital. A total of 9364 patients were included in the registry, of which 623 patients were analyzed for levels of total cholesterol, low-density lipoprotein cholesterol (LDL-C) and triglycerides on days 1-2 of hospitalization. The level of high-density lipoprotein cholesterol (HDL-C) was calculated using the Friedewald equation. Results. We found that a decrease in LDL-C level was significantly associated with an unfavorable prognosis for hospitalized patients with COVID-19. This pattern persisted in both univariate and multivariate analyses. LDL-C levels in the final multivariate model had a significant relationship with the prognosis (an increase in the death risk by 1,7 times with a decrease per 1 mmol/l). In addition, we found that the survival of patients with an indicator level of <2,45 mmol/l is significantly worse than in patients with an LDL-C level ≥2,45 mmol/l. All patients with high LDL-C ((≥4,9 mmol/l) survived, while among patients with low LDL-C (<1,4 mmol/l), mortality was 13,04%, which was significantly higher than in patients with LDL-C ≥1,4 mmol/l (6,32%, p=0,047). Conclusion. A decrease in LDL-C in the acute period is significantly associated with an unfavorable prognosis for hospitalized patients with COVID-19. Determination of LDL-C can be included in the examination program for patients with COVID-19. However, the predictive value of this parameter requires further study in prospective clinical studies.

Cholesterol , COVID-19 , Low density lipoproteins

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Eurasian Association of Therapists, Moscow, Russian Federation
Pirogov Russian National Research Medical University, Moscow, Russian Federation
Privolzhsky Research Medical University, Nizhny Novgorod, Russian Federation
I. M. Sechenov First Moscow State Medical University, Moscow, Russian Federation
Almazov National Medical Research Center, St. Petersburg, Russian Federation
Volgograd State Medical University, Volgograd, Russian Federation
Saratov State Medical University, Saratov, Russian Federation
E. I. Chazov National Medical Research Center for Cardiology, Moscow, Russian Federation
Rostov State Medical University, Rostov-on-Don, Russian Federation
Erebuni Medical Center, Cardiology and Cardiovascular Surgery Clinic, Yerevan, Armenia
Nicolae Testemițanu State University of Medicine and Pharmacy, Chisinau, Moldova
I. I. Mechnikov North-Western State Medical University, St. Petersburg, Russian Federation
Ogarev Mordovia National Research University, Republic of Mordovia, Saransk, Russian Federation
Pavlov First Saint Petersburg State Medical University, St. Petersburg, Russian Federation
Republican Center for Cardiovascular Diseases, Republic of Tatarstan, Kazan, Russian Federation
Kazan State Medical University, Republic of Tatarstan, Kazan, Russian Federation
Lobachevsky State University of Nizhny Novgorod, National Research University, Nizhny Novgorod, Russian Federation
Samara State Medical University, Samara, Russian Federation
Regional Clinical Hospital, Krasnoyarsk, Russian Federation
V. F. Voino-Yasenetsky Krasnoyarsk State Medical University, Krasnoyarsk, Russian Federation
Krasnogorsk city hospital № 1, Moscow region, Krasnogorsk, Russian Federation
Kirov Clinical Interdistrict Hospital, Leningrad region, Russian Federation
City Clinical Hospital № 51 DZM, Moscow, Russian Federation
Republican Specialized Scientific and Practical Medical Center for Therapy and Medical Rehabilitation, Tashkent, Uzbekistan
City Clinical Hospital № 7, Republic of Tatarstan, Kazan, Russian Federation
Petrozavodsk State University, Republic of Karelia, Petrozavodsk, Russian Federation
Chita State Medical Academy, Chita, Russian Federation
Kirov State Medical University, Kirov, Russian Federation
City Clinical Hospital № 13, Nizhny Novgorod, Russian Federation
Irkutsk State Medical Academy of Postgraduate Education, Irkutsk, Russian Federation
City Clinical Hospital № 40, Moscow, Russian Federation
Gomel State Medical University, Gomel, Belarus
Mirrakhimov National Center for Cardiology and Therapy, Bishkek, Kyrgyzstan
Asfendiyarov Kazakh National Medical University, Alma-Ata, Kazakhstan
E. A. Vagner Perm State Medical University, Perm, Russian Federation
South Ural State Medical University, Chelyabinsk, Russian Federation
Kazakh Medical University of Continuing Education, Alma-Ata, Kazakhstan
Zhekenov City Clinical Infectious Diseases Hospital, Alma-Ata, Kazakhstan
Yerevan State Medical University, Yerevan, Armenia
Central Clinical Hospital with a Polyclinic, Moscow, Russian Federation
Clinical Cardiology Dispensary, Perm, Russian Federation
Privolzhsky District Medical Center of the Federal Medical and Biological Agency of Russia, Nizhny Novgorod, Russian Federation
City Clinical Hospital № 1, Chisinau, Moldova
Polyclinic № 1 of the Administrative Department of the President of the Russian Federation, Moscow, Russian Federation
Perm Regional Clinical Hospital, Perm, Russian Federation
Chapaevskaya Сentral Сity Hospital, Samara region, Chapaevsk, Russian Federation
V. A. Baranov Republican Hospital, Republic of Karelia, Petrozavodsk, Russian Federation
OOO EMPATIYA, Reutov, Russian Federation
City Clinical Hospital № 25, Novosibirsk, Russian Federation
Hospital for War Veterans, Republic of Karelia, Petrozavodsk, Russian Federation
Railway Clinical Hospital, Samara, Russian Federation
Irkutsk Regional Clinical Hospital, Irkutsk, Russian Federation
City Clinical Hospital № 40, Nizhny Novgorod, Russian Federation
City Polyclinic № 134, Moscow, Russian Federation
City Clinical Hospital № 1, Chelyabinsk, Russian Federation
City Clinical Hospital № 5, Nizhny Novgorod, Russian Federation
Gorodetsk Central District Hospital, Nizhny Novgorod region, Gorodets, Russian Federation
S. V. Katkov Republican Clinical Hospital, Republic of Mordovia, Saransk, Russian Federation
City Polyclinic № 1, Republic of Karelia, Petrozavodsk, Russian Federation
Global Medical System Сlinics and Рospitals, Moscow, Russian Federation
City Clinical Hospital № 4, Moscow, Russian Federation
Republican Anti-tuberculosis Clinic, Republic of Karelia, Petrozavodsk, Russian Federation
Briceni Health Center, Briceni, Moldova
City Clinical Hospital № 38, Nizhny Novgorod, Russian Federation
MC Zimamed, Krasnodar, Russian Federation
Hospital for War Veterans, St. Petersburg, Russian Federation
AO Laboratorii Budushchego, Moscow, Russian Federation
Novosibirsk State Medical University, Novosibirsk, Russian Federation
Novosibirsk Regional Clinical Hospital for War Veterans № 3, Novosibirsk, Russian Federation
OOO Fresenius Medical Care Kuban, Krasnodar, Russian Federation
City Clinical Hospital № 3, Nizhny Novgorod, Russian Federation
City Polyclinic № 1, Nizhny Novgorod, Russian Federation
Republican Clinical Hospital № 4, Republic of Mordovia, Saransk, Russian Federation
AO GK MEDSI KB2, Moscow, Russian Federation
Samara City Polyclinic № 3, Samara, Russian Federation
Kazan State Medical Academy, Republic of Tatarstan, Kazan, Russian Federation

Eurasian Association of Therapists
Pirogov Russian National Research Medical University
Privolzhsky Research Medical University
I. M. Sechenov First Moscow State Medical University
Almazov National Medical Research Center
Volgograd State Medical University
Saratov State Medical University
E. I. Chazov National Medical Research Center for Cardiology
Rostov State Medical University
Erebuni Medical Center
Nicolae Testemițanu State University of Medicine and Pharmacy
I. I. Mechnikov North-Western State Medical University
Ogarev Mordovia National Research University
Pavlov First Saint Petersburg State Medical University
Republican Center for Cardiovascular Diseases
Kazan State Medical University
Lobachevsky State University of Nizhny Novgorod
Samara State Medical University
Regional Clinical Hospital
V. F. Voino-Yasenetsky Krasnoyarsk State Medical University
Krasnogorsk city hospital № 1
Kirov Clinical Interdistrict Hospital
City Clinical Hospital № 51 DZM
Republican Specialized Scientific and Practical Medical Center for Therapy and Medical Rehabilitation
City Clinical Hospital № 7
Petrozavodsk State University
Chita State Medical Academy
Kirov State Medical University
City Clinical Hospital № 13
Irkutsk State Medical Academy of Postgraduate Education
City Clinical Hospital № 40
Gomel State Medical University
Mirrakhimov National Center for Cardiology and Therapy
Asfendiyarov Kazakh National Medical University
E. A. Vagner Perm State Medical University
South Ural State Medical University
Kazakh Medical University of Continuing Education
Zhekenov City Clinical Infectious Diseases Hospital
Yerevan State Medical University
Central Clinical Hospital with a Polyclinic
Clinical Cardiology Dispensary
Privolzhsky District Medical Center of the Federal Medical and Biological Agency of Russia
City Clinical Hospital № 1
Polyclinic № 1 of the Administrative Department of the President of the Russian Federation
Perm Regional Clinical Hospital
Chapaevskaya Сentral Сity Hospital
V. A. Baranov Republican Hospital
OOO EMPATIYA
City Clinical Hospital № 25
Hospital for War Veterans
Railway Clinical Hospital
Irkutsk Regional Clinical Hospital
City Clinical Hospital № 40
City Polyclinic № 134
City Clinical Hospital № 1
City Clinical Hospital № 5
Gorodetsk Central District Hospital
S. V. Katkov Republican Clinical Hospital
City Polyclinic № 1
Global Medical System Сlinics and Рospitals
City Clinical Hospital № 4
Republican Anti-tuberculosis Clinic
Briceni Health Center
City Clinical Hospital № 38
MC Zimamed
Hospital for War Veterans
AO Laboratorii Budushchego
Novosibirsk State Medical University
Novosibirsk Regional Clinical Hospital for War Veterans № 3
OOO Fresenius Medical Care Kuban
City Clinical Hospital № 3
City Polyclinic № 1
Republican Clinical Hospital № 4
AO GK MEDSI KB2
Samara City Polyclinic № 3
Kazan State Medical Academy

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