Lipid profile changes after the acute COVID-19 period. Sub-analysis of the International Registry Dynamics Analysis of Comorbidities in SARS-CoV-2 Survivors (AKTIV SARS-CoV-2) (12-month follow-up)

Arutyunov G.P. Tarlovskaya E.I. Arutyunov A.G. Polyakov D.S. Grigorieva N.Yu. Gubareva I.V. Kamilova U.K. Kim Z.F. Kuznetsova A.S. Kuznetsova T.Yu. Ruzanov D.Yu. Svarovskaya A.V. Smirnova E.A. Sugraliev A.B. Frolova I.A. Aimakhanova G.T. Batluk T.I. Bashkinov R.A. Bikushova I.V. Gordeychuk E.D. Gubareva E.Yu. Evdokimov D.S. Zakirova G.A. Loginova A.O. Melnikov E.S. Moiseenko N.B. Trubnikova M.A. Shcherbakov S.Y.
2024 Silicea-Poligraf

Russian Journal of Cardiology
2024 #29 Issue 3 51 - 63 pp.

Aim. To analyze the lipid profile changes during the acute phase of coronavirus disease 2019 (COVID-19) and within 12 months after discharge from the hospital (post-Covid period) in comparison with the lipid profile of patients before COVID-19. Material and methods. The subanalysis of the registry was carried out as follows: clinical investigators in each of the centers included patients in the AKTIV registry selected from the database patients who met three following criteria: (1) availability of lipid profile test no more than 60 days before COVID-19; (2) availability of lipid profile test during the acute period; (3) availability of lipid profile test within 6-12 months after discharge from the hospital. Results. In patients after COVID-19, a decrease in the levels of all lipid profile parameters in the acute COVID-19 phase and their subsequent increase were found. In the post-COVID-19 period, 25,7% of patients experienced an increase in lipid profile parameters (increased levels of total cholesterol (TC) and/or cholesterol, low-density lipoproteins and/or triglycerides and/or cholesterol excluding high-density lipoproteins by ≥0,5 mmol/l) despite the fact that lipid-lowering therapy in these patients was at least no worse than in patients without lipid profile changes. Multivariate analysis found that such variables as age (direct relationship), body mass index (direct relationship), estimated glomerular filtration rate in the acute phase (inverse relationship) and cholesterol level excluding high-density lipoproteins in the acute period (inverse relationship), as well as heart failure, obesity and cytokine storm in the acute COVID-19 phase are independent predictors of an increase in one or more lipid parameters by ≥0,5 mmol/l over 6-12 months of post-COVID-19 period. Conclusion. COVID-19 likely contributes to the onset and/or progression of lipid metabolism disorders in COVID-19 survivors (Eurasian population).

COVID-19 , dyslipidemia , lipid profile

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Eurasian Association of Therapists, Moscow, Russian Federation
Pirogov Russian National Research Medical University, Moscow, Russian Federation
Privolzhsky Research Medical University, Nizhny Novgorod, Russian Federation
S. Avdalbekyan National Institute of Health, Yerevan, Armenia
Lobachevsky National Research State University, Nizhny Novgorod, Russian Federation
Samara State Medical University, Samara, Russian Federation
Republican Specialized Scientific and Practical Medical Center for Therapy and Medical Rehabilitation, Tashkent, Uzbekistan
City Clinical Hospital № 7 of Kazan, Kazan, Russian Federation
South Ural State Medical University, Chelyabinsk, Russian Federation
Petrozavodsk State University, Petrozavodsk, Russian Federation
Gomel State Medical University, Gomel, Belarus
Cardiology Research Institute, Tomsk National Medical Research Center, Tomsk, Russian Federation
Ryazan State Medical University, Ryazan, Russian Federation
Asfendiyarov Kazakh National Medical University, Alma-Ata, Kazakhstan
Privolzhsky District Medical Center of the Federal Medical and Biological Agency, Nizhny Novgorod, Russian Federation
I. I. Mechnikov North-Western State Medical University, St. Petersburg, Russian Federation
Research Institute - Korolev Specialized Cardiac Surgery Clinical Hospital, Nizhny Novgorod, Russian Federation
LLC Fomin Clinic, Sochi, Russian Federation
Kazan State Medical Academy — branch of the Russian Medical Academy of Continuous Professional Education, Kazan, Russian Federation

Eurasian Association of Therapists
Pirogov Russian National Research Medical University
Privolzhsky Research Medical University
S. Avdalbekyan National Institute of Health
Lobachevsky National Research State University
Samara State Medical University
Republican Specialized Scientific and Practical Medical Center for Therapy and Medical Rehabilitation
City Clinical Hospital № 7 of Kazan
South Ural State Medical University
Petrozavodsk State University
Gomel State Medical University
Cardiology Research Institute
Ryazan State Medical University
Asfendiyarov Kazakh National Medical University
Privolzhsky District Medical Center of the Federal Medical and Biological Agency
I. I. Mechnikov North-Western State Medical University
Research Institute - Korolev Specialized Cardiac Surgery Clinical Hospital
LLC Fomin Clinic
Kazan State Medical Academy — branch of the Russian Medical Academy of Continuous Professional Education

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