Impact of vaccination status on the clinical course and outcomes of acute COVID-19 period: data from the international registry Dynamics Analysis of Comorbidities in SARS-CoV-2 Survivors (AKTIV-4)
Arutyunov G.P. Tarlovskaya E.I. Arutyunov A.G. Polyakov D.S. Lopatin Y.M. Chesnikova A.I. Balykova L.A. Vaisberg A.R. Galyavich A.S. Grigorieva N.Y. Grinevich V.B. Gubareva I.V. Demko I.V. Zharkov A.V. Zaitsev D.N. Kim Z.F. Korobka V.L. Lareva N.V. Makarova E.V. Malchikova S.V. Nedogoda S.V. Obrezan A.G. Hovakimyan A.G. Pereverzev S.V. Petrova M.M. Pochinka I.G. Protasov K.V. Protsenko D.N. Rebrov A.P. Rubanenko O.A. Ruzanov D.Y. Svarovskaya A.V. Selezneva N.M. Smirnova E.A. Sygraliev A.B. Khlynova O.V. Shaposhnik I.I. Shchukarev D.A. Abdrakhmanova A.K. Abdualimov T.P. Agafonov A.V. Hakobjanyan V.G. Allahkuliyeva L.N. Aparkina A.V. Barysheva O.Y. Batluk T.I. Batchayeva A.S. Bashkinov R.A. Belenikina Y.A. Bikushova I.V. Botabekova A.Z. Botova S.N. Bochkareva V.O. Bykova G.A. Vagapova K.R. Vasilev V.V. Vezikova N.N. Viktorov K.S. Genkel V.V. Girivenko A.I. Girich O.P. Godunko E.S. Gordeeva N.V. Gordeychuk E.D. Gorshenina E.I. Grigorieva E.V. Gubareva E.Yu. Davydkin I.L. Duisenova A.K. Evdokimov D.S. Evdokimova L.S. Zheldybayeva A.E. Zimina Y.D. Zolotovskaya I.A. Ivanchenko E.Y. Izhanova A.K. Kazakovtseva M.V. Ghazaryan S.F. Kaidarbek M.K. Karetnikov I.A. Karoli N.A. Kaskaeva D.S. Kim E.S. Kozlov E.V. Koliev V.I. Koliadich M.I. Konstantinov D.Yu. Konstantinova E.A. Konusova A.K. Korobka A.V. Korolev A.A. Kosacheva N.B. Kravchuk Y.A. Kraposhina A.Yu. Kryukova T.V. Kuznetsova A.S. Kuzmichev K.V. Kuchiyash O.Yu. Lebedeva Y.I. Levina T.M. Levchenko K.V. Levshin A.V. Ledyaeva A.A. Lisun T.V. Lyubavina N.A. Lyubimov M.V. Magdeyeva N.A. Mazhara O.A. Maiseenko V.I. Makarova A.S. Ma-Van-de V.D. Matuzkova A.A. Mashkunova O.V. Melnikov E.S. Moiseenko N.B. Mukha N.V. Nikitina N.M. Oblavatckii D.V. Obukhova I.A. Obukhova O.V. Ospanova S.O. Plastinina S.S. Pogrebetskaya V.A. Polyakov D.V. Ponomarenko E.V. Popova L.L. Popov M.V. Rubanenko A.O. Rusinova O.A. Rustamova F.E. Sadykova A.M. Seliverstov P.V. Serikbolkyzy S. Sinkevich D.A. Solovieva I.A. Stepina E.A. Suchkova E.I. Tokmin D.S. Tolmacheva A.A. Trofimov D.A. Trubnikova M.A. Tulichev A.A. Tuchin I.A. Ualieva S.T. Ulanova N.D. Fedorishina O.V. Khaletskaya A.I. Hamidov S.H. Khokhlova L.N. Khusainova L.N. Tsoma V.V. Chudinovskikh T.I. Shabelsky А.O. Shvidko A.O. Shishkina E.A. Shostak-Kritskii S.S. Sherbakov S.Yu. Yarigina M.I.
2025Silicea-Poligraf
Russian Journal of Cardiology
2025#30Issue 3
Aim. To assess the effectiveness of vaccination against Omicron and Delta variants according to the international registry Dynamics Analysis of Comorbidities in SARS-CoV-2 Survivors (AKTIV-4). Material and methods. The AKTIV-4 registry included men and women over 18 years of age with a diagnosis of coronavirus disease 2019 (COVID-19) (oropharyngeal and nasopharyngeal swabs, SARS-CoV-2 antibody titers, typical computed tomography performance), undergoing hospital treatment. A total of 3543 patients from 25 medical centers in 7 countries (the Russian Federation, the Republic of Armenia, the Republic of Belarus, the Republic of Kazakhstan, the Kyrgyz Republic, the Republic of Moldova, and the Republic of Uzbekistan) were included in the AKTIV-4 registry. Results. The clinical status of patients from the AKTIV-4 registry was more severe than in the AKTIV-1 and AKTIV-2 registries. Patients in the AKTIV-4 registry were older than patients in the AKTIV-1 registry. The inhospital mortality rate in patients in the AKTIV-4 registry was higher (8,41%, p<0,001) than in the population of patients in the AKTIV-1 (7,60%) and AKTIV-2 (4,80%) registries. Of the 3543 patients included in AKTIV-4, 36% were vaccinated. Among the vaccines, Sputnik V (Gam-COVID-Vac) was the leader in primary and repeated vaccination, used in 77,8%and 61,0%, respectively. In the population of unvaccinated patients, there were more patients with a high risk of an unfavorable prognosis than in the vaccinated as follows: older age, coronary artery disease, class 3-4 heart failure, atrial fibrillation, chronic kidney disease, and anemia. Unvaccinated patients had a higher volume of lung damage compared to vaccinated patients, and bacterial pneumonia and acute respiratory distress syndrome developed more often. Among those who died in hospital, unvaccinated patients predominated (89,14%). Inhospital mortality for unvaccinated patients was 9,9%, while for vaccinated ones — 3,3% (odds ratio (OR) 0,31 [0,20;0,45], p<0,001). In patients within 3, 4-6, and ≥7 months after vaccination, the mortality rate was 3,12% (OR 0,30 [0,16;0,51], p<0,001), 4,00% (OR 0,39 [0,20;0,67], p<0,001), and 2,96% (OR 0,29 [0,09;0,70], p<0,001). Inhospital mortality of vaccinated patients did not differ significantly depending on the type of vaccine. Conclusion. Vaccination, primarily with Sputnik V, is an independent predictor of survival in hospitalized COVID-19 patients and reduces the risk of death by 62% according to multivariate analysis.
COVID-19 , vaccination
Text of the article Перейти на текст статьи
Association Eurasian Association of Therapists, Moscow, Russian Federation
Pirogov Rus-sian National Research Medical University, Moscow, Russian Federation
Privolzhsky Research Medical University, Nizhny Novgorod, Russian Federation
Avdalbekyan National Institute of Health, Yerevan, Armenia
Lobachevsky National Research Nizhny Novgorod State University, Nizhny Novgorod, Russian Federation
Volgograd State Medical University, Volgo-grad, Russian Federation
Rostov State Medical University, Rostov-on-Don, Russian Federation
Ogarev National Research Mordovia State University, Saransk, Russian Federation
Kazan State Me-dical University, Kazan, Russian Federation
Interregional Clinical Diagnostic Center, Kazan, Russian Federation
S. M. Kirov Military Medical Academy, St. Petersburg, Russian Federation
Samara State Medical University, Samara, Russian Federation
V. F. Voino-Yasenetsky Krasnoyarsk state medical University, Krasnoyarsk, Russian Federation
Regional Clinical Hospital, Krasno-yarsk, Russian Federation
Kirovsk clinical interdistrict hospital, Kirovsk, Russian Federation
Chita State Medical Academy, Chita, Russian Federation
City Clinical Hospital № 7, Kazan, Russian Federation
Rostov Regional Clinical Hospital, Rostov-on-Don, Russian Federation
Nizhny Novgorod Research Institute of Hygiene and Occupational Pathology of Rospotrebnadzor, Nizhny Novgorod, Russian Federation
Kirov State Medical University, Kirov, Russian Federation
Saint Petersburg State University, St. Petersburg, Russian Federation
My Medical Center Group, St. Petersburg, Russian Federation
Saint Gregory The Illuminator Medical Center, Yerevan, Armenia
Cardiology Research Institute, Tomsk National Research Medical Centre, Tomsk, Russian Federation
Nizhny Novgorod Region City Clinical Hospital № 13, Nizhny Novgorod, Russian Federation
Irkutsk State Medical Academy-a branch of the Russian Medical Academy of Continuing Professional Education, Irkutsk, Russian Federation
Moscow Multidisciplinary Clinical Center Kommunarka of the Department of Healthcare of the City of Moscow, Moscow, Russian Federation
V. I. Razumovsky Saratov State Medical University, Saratov, Russian Federation
Gomel State Medical University, Gomel, Belarus
Pavlov Ryazan State Medical University, Ryazan, Russian Federation
Asfendiyarov Kazakh National Medical University, Almaty, Kazakhstan
E.A. Vagner Perm State Medical University, Perm, Russian Federation
South-Ural State Medical University, Che-lyabinsk, Russian Federation
I. Zhekenova Clinical Infectious Diseases Hospital, Almaty, Kazakhstan
International Medical Center SOGAZ, St. Petersburg, Russian Federation
Petrozavodsk State University, Petrozavodsk, Russian Federation
I. I. Mechnikov North-Western State Medical University, St. Petersburg, Russian Federation
Clinical Rheumatology Hospital № 25, St. Petersburg, Russian Federation
N. S. Karpovich Krasnoyarsk Interdistrict Clinical Emergency Hospital, Krasnoyarsk, Russian Federation
Polyclinic № 1 of the Admi-nistrative Directorate of the President of the Russian Federation, Moscow, Russian Federation
City Polyclinic № 38, St. Petersburg, Russian Federation
Childrens policlinic № 49, St. Petersburg, Russian Federation
Russian Scientific Medical Society of Therapists, Mos-cow, Russian Federation
Novosibirsk State Medical University, Novosibirsk, Russian Federation
Novosi-birsk Regional Clinical Hospital for War Veterans № 3, Novosibirsk, Russian Federation
Irkutsk regional clinical hospital of Conferred Order of Merit, Irkutsk, Russian Federation
City Clinical Hospital № 1, Chelyabinsk, Russian Federation
Asinovskaya District Hospital, Tomsk region, Russian Federation
City Clinical Hospital № 40 of the Moscow Department of Healthcare, Moscow, Russian Federation
Forensic Medical Examination Bureau of the Leningrad Region, St. Petersburg, Russian Federation
Nizhny Novgorod Infectious Disease Hospital № 2, Nizhny Novgorod, Russian Federation
City Clinical Hospital № 38, Nizhny Novgorod, Russian Federation
LLC Formula of Health, Krasnodar, Russian Federation
LLC Clinic Expert, Irkutsk, Russian Federation
Alphastat analytic agency, Moscow, Russian Federation
LLC Dr. Fomins clinic, Sochi, Russian Federation
Nizhniy Novgorod region City Clinical Hospital № 3, Nizhny Novgorod, Russian Federation
St. George City Hospital, St. Petersburg, Russian Federation
Alexander hospital, St. Petersburg, Russian Federation
International Medical Center SOGAZ PROFMEDICINA, Svobodny, Russian Federation
Association Eurasian Association of Therapists
Pirogov Rus-sian National Research Medical University
Privolzhsky Research Medical University
Avdalbekyan National Institute of Health
Lobachevsky National Research Nizhny Novgorod State University
Volgograd State Medical University
Rostov State Medical University
Ogarev National Research Mordovia State University
Kazan State Me-dical University
Interregional Clinical Diagnostic Center
S. M. Kirov Military Medical Academy
Samara State Medical University
V. F. Voino-Yasenetsky Krasnoyarsk state medical University
Regional Clinical Hospital
Kirovsk clinical interdistrict hospital
Chita State Medical Academy
City Clinical Hospital № 7
Rostov Regional Clinical Hospital
Nizhny Novgorod Research Institute of Hygiene and Occupational Pathology of Rospotrebnadzor
Kirov State Medical University
Saint Petersburg State University
My Medical Center Group
Saint Gregory The Illuminator Medical Center
Cardiology Research Institute
Nizhny Novgorod Region City Clinical Hospital № 13
Irkutsk State Medical Academy-a branch of the Russian Medical Academy of Continuing Professional Education
Moscow Multidisciplinary Clinical Center Kommunarka of the Department of Healthcare of the City of Moscow
V. I. Razumovsky Saratov State Medical University
Gomel State Medical University
Pavlov Ryazan State Medical University
Asfendiyarov Kazakh National Medical University
E.A. Vagner Perm State Medical University
South-Ural State Medical University
I. Zhekenova Clinical Infectious Diseases Hospital
International Medical Center SOGAZ
Petrozavodsk State University
I. I. Mechnikov North-Western State Medical University
Clinical Rheumatology Hospital № 25
N. S. Karpovich Krasnoyarsk Interdistrict Clinical Emergency Hospital
Polyclinic № 1 of the Admi-nistrative Directorate of the President of the Russian Federation
City Polyclinic № 38
Childrens policlinic № 49
Russian Scientific Medical Society of Therapists
Novosibirsk State Medical University
Novosi-birsk Regional Clinical Hospital for War Veterans № 3
Irkutsk regional clinical hospital of Conferred Order of Merit
City Clinical Hospital № 1
Asinovskaya District Hospital
City Clinical Hospital № 40 of the Moscow Department of Healthcare
Forensic Medical Examination Bureau of the Leningrad Region
Nizhny Novgorod Infectious Disease Hospital № 2
City Clinical Hospital № 38
LLC Formula of Health
LLC Clinic Expert
Alphastat analytic agency
LLC Dr. Fomins clinic
Nizhniy Novgorod region City Clinical Hospital № 3
St. George City Hospital
Alexander hospital
International Medical Center SOGAZ PROFMEDICINA
10 лет помогаем публиковать статьи Международный издатель
Книга Публикация научной статьи Волощук 2026 Book Publication of a scientific article 2026