Clinical features of post-covid period. Results of an international register dynamics analysis of comorbidities in SARS-CoV-2 survivors (ACTIV SARS-cov-2) (12-month follow-up)

Arutyunov G.P. Tarlovskaya E.I. Arutyunov A.G. Belenkov Y.N. Konradi A.O. Lopatin Y.M. Rebrov A.P. Tereshchenko S.N. Chesnikova A.I. Hayrapetyan H.G. Babin A.P. Bakulin I.G. Bakulina N.V. Balykova L.A. Blagonravova A.S. Boldina M.V. Butomo M.I. Vaisberg A.R. Galyavich A.S. Gomonova V.V. Grigoryeva N.Yu. Gubareva I.V. Demko I.V. Evzerikhina A.V. Zharkov A.V. Zateishchikova A.A. Kamilova U.K. Kim Z.F. Kuznetsova T.Yu. Kulikov A.N. Lareva N.V. Makarova E.V. Malchikova S.V. Nedogoda S.V. Petrova M.M. Pochinka I.G. Protasov K.V. Protsenko D.N. Ruzanov D.Yu. Saiganov S.A. Sarybaev A.Sh. Selezneva N.M. Sugraliev A.B. Fomin I.V. Khlynova O.V. Chizhova O.Yu. Shaposhnik I.I. Schukarev D.A. Abdrakhmanova A.K. Avetisyan S.A. Avoyan H.G. Azaryan K.K. Aimakhanova G.T. Ayypova D.A. Akunov A.Ch. Alieva M.K. Almukhambedova A.R. Aparkina A.V. Aruslanova O.R. Ashina E.Yu. Badina O.Yu. Barysheva O.Yu. Batluk T.I. Batchaeva A.S. Bashkinov R.A. Bitieva A.M. Bikhteev I.U. Borodulina N.A. Bragin M.V. Brazhnik V.A. Budu A.M. Bykova G.A. Vagapova K.R. Varlamova D.D. Vezikova N.N. Verbitskaya E.A. Vilkova O.E. Vinnikova E.A. Vustina V.V. Galova E.A. Genkel V.V. Giller D.B. Gorshenina E.I. Grigoryeva E.V. Gubareva E.Yu. Dabylova G.M. Demchenko A.I. Dolgikh O.Yu. Duishobaev M.Y. Evdokimov D.S. Egorova K.E. Zheldybaeva A.E. Zarechnova N.V. Zimina Y.D. Ivanova S.Yu. Ivanchenko E.Yu. Ilina M.V. Kazakovtseva M.V. Kazymova E.V. Kalinina Y.S. Kamardina N.A. Karachenova A.M. Karetnikov I.A. Karoli N.A. Karsiev M.K. Kaskaeva D.S. Kasymova K.F. Kerimbekova Z.B. Kim E.S. Kiseleva N.V. Klimenko D.A. Kovalishena O.V. Kozlov S.V. Kolmakova E.V. Kolchinskaya T.P. Kolyadich M.I. Kondryakova O.V. Konoval M.P. Konstantinov D.Y. Konstantinova E.A. Kordyukova V.A. Koroleva E.V. Kraposhina A.Yu. Kryukova T.V. Kuznetsova A.S. Kuzmina T.Y. Kuzmichev K.V. Kulchoroeva C.K. Kuprina T.V. Kuranova I.M. Kurenkova L.V. Kurchugina N.Yu. Kushubakova N.A. Levankova V.I. Ledyaeva A.A. Lisun T.V. Lisyanskaya V.E. Lyubavina N.A. Magdeeva N.A. Mazalov K.V. Mayseenko V.I. Makarova A.S. Maripov A.M. Markov N.V. Marusina A.A. Melnikov E.S. Metlinskaya A.I. Moiseenko N.B. Muradova F.N. Muradyan R.G. Musaelyan S.N. Nekaeva E.S. Nikitina N.M. Nifontov S.E. Obolentseva E.Yu. Obukhova A.A. Ogurlieva B.B. Odegova A.A. Omarova Y.V. Omurzakova N.A. Ospanova S.O. Pavlova V.A. Pakhomova E.V. Petrov L.D. Plastinina S.S. Platonov D.A. Pogrebetskaya V.A. Polyakov D.V. Polyakov D.S. Ponomarenko E.V. Popova L.L. Potanin A.A. Prokofieva N.A. Rabik Y.D. Rakov N.A. Rakhimov A.N. Rozanova N.A. Samus I.V. Serikbolkyzy S. Sidorkina Y.A. Simonov A.A. Skachkova V.V. Skvortsova R.D. Skuridin D.S. Solovieva D.V. Solovieva I.A. Sukhomlinova I.M. Sushilova A.G. Tagaeva D.R. Tikhonova E.P. Tokmin D.S. Tolmacheva A.A. Torgunakova M.S. Trenogina K.V. Trostyanetskaya N.A. Trofimov D.A. Trubnikova M.A. Tulichev A.A. Tursunova A.T. Ulanova N.D. Fatenkov O.V. Fedorishina O.V. Fil T.S. Fomina I.Yu. Fominova I.S. Frolova I.A. Tsvinger S.M. Tsoma V.V. Cholponbaeva M.B. Chudinovskikh T.I. Shavrin I.V. Shevchenko O.A. Shikhaliev D.R. Shishkina E.A. Shishkov K.Yu. Shcherbakov S.Yu. Shcherbakova G.V. Yausheva E.A.
2023 Silicea-Poligraf

Russian Journal of Cardiology
2023 #28 Issue 1 9 - 27 pp.

Aim. To investigate on post-COVID period in patients of the Eurasian region. Material and methods. A total of 9364 consecutively hospitalized patients were included in ACTIV registry. Enrollment of patients began on June 29, 2020, and was completed on March 30, 2021, corresponding to the first and second waves of the pandemic. Demographic, clinical, and laboratory data, computed tomography (CT) results, information about inhospital clinical course and complications of COVID-19 during hospitalization were extracted from electronic health records using a standardized data collection form. The design included follow-up telephone interviews with a standard questionnaire at 3, 6, and 12 months to examine the course of post-COVID period. Results. According to ACTIV register, 63% of patients after COVID-19 had new adverse symptoms or exacerbations of the existing symptoms lasting for up to 1 year. After hospital discharge, 79,8% of patients sought unscheduled medical attention in the first 3 months, 79,1% at 4-6 months, and 64,8% at 7-12 months. Readmission rate was 11,8% in the first 3 months, 10,9% at 4-6 months, and 10,1% at 7-12 months. The most common reasons for unscheduled treatment in the first 3 months were uncontrolled hypertension, decompensated type 2 diabetes, destabilization of coronary artery disease, gastrointestinal disease, AF episodes, exacerbation of asthma and chronic obstructive pulmonary disease, decompensated heart failure (HF). The 12-month mortality of COVID-19 survivors after the discharge was 3,08%. Multivariate analysis showed that independent risk factors for fatal outcome were age (direct correlation), the levels of hemoglobin (inverse correlation), oxygen saturation (inverse correlation), and aspartate aminotransferase (direct correlation), as well as class III-IV HF, prior stroke, cancer, inhospital acute kidney injury. Based on these identified risk factors, a nomogram was constructed to determine the 3-month mortality risk after discharge. Conclusion. Analysis of ACTIV register showed that end of the acute phase of COVID-19 does not imply a complete recovery.

COVID-19 , Post-COVID period , Readmissions

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Eurasian Association of Therapists, Moscow, Russian Federation
Pirogov Russian National Research Medical University, Moscow, Russian Federation
Privolzhsky Research Medical University, Nizhny Novgorod, Russian Federation
S. Avdalbekyan National Institute of Health, Yerevan, Armenia
I. M. Sechenov First Moscow State Medical University, Moscow, Russian Federation
Almazov National Medical Research Centre, St. Petersburg, Russian Federation
Volgograd State Medical University, Volgograd, Russian Federation
V. I. Razumovsky Saratov State Medical University, Saratov, Russian Federation
E. I. Chazov National medical research center of cardiology, Moscow, Russian Federation
Rostov State Medical University, Rostov-on-Don, Russian Federation
Erebouni Cardiology Center, Cardiology and Cardiac Surgery Clinic, Yerevan, Armenia
Nicolae Testemitanu State University of Medicine and Pharmacy, Kishinev, Moldova
I. I. Mechnikov North-Western State Medical University, St. Petersburg, Russian Federation
Ogarev Mordovia State University, Saransk, Russian Federation
Pavlov First St. Petersburg State Medical University, St. Petersburg, Russian Federation
Interregional Clinical Diagnostic Center, Kazan, Russian Federation
Kazan State Medical University, Kazan, Russian Federation
Lobachevsky Nizhny Novgorod National Research State University, Nizhny Novgorod, Russian Federation
Samara State Medical University, Samara, Russian Federation
V. F. Voino-Yasenetsky Krasnoyarsk state medical University, Krasnoyarsk, Russian Federation
Regional Clinical Hospital, Krasnoyarsk, Russian Federation
Krasnogorsk city hospital № 1, Krasnogorsk, Russian Federation
Kirovsk Interdistrict Hospital, Kirovsk, Russian Federation
City Hospital № 51, Moscow, Russian Federation
Republican Specialized Scientific and Practical Medical Center for Therapy and Medical Rehabilitation, Tashkent, Uzbekistan
Medical Center GAUZ GKB № 7, Kazan, Russian Federation
Petrozavodsk State University, Petrozavodsk, Russian Federation
Chita State Medical Academy, Chita, Russian Federation
Kirov State Medical University, Kirov, Russian Federation
City Clinical Hospital № 13 of Nizhniy Novgorod, Nizhny Novgorod, Russian Federation
Irkutsk State Medical Academy of Postgraduate Education, Irkutsk, Russian Federation
Moscow City Clinical Hospital № 40, Moscow, Russian Federation
Gomel State Medical University, Gomel, Belarus
M. Mirrakhimov National Center of Cardiology and Internal Medicine, Bishkek, Kyrgyzstan
Asfendiyarov Kazakh National Medical University, Alma-Ata, Kazakhstan
E. A. Vagner Perm State Medical University, Perm, Russian Federation
Kazakh University of Continuing Education, Alma-Ata, Kazakhstan
I. Zhekenovа Clinical Infectious Diseases Hospital, Alma-Ata, Kazakhstan
Yerevan State Medical University, Yerevan, Armenia
Central Clinical Hospital with Polyclinic of the Office of the President of RF, Moscow, Russian Federation
Perm Regional Clinical Cardiology Dispensary, Perm, Russian Federation
The Volga District Medical Centre, Nizhny Novgorod, Russian Federation
Clinical City Hospital № 1 of Kishinev, Kishinev, Moldova
Polyclinic № 1 Polyclinic of the Office of the President of RF, Moscow, Russian Federation
Perm Regional Clinical Hospital, Perm, Russian Federation
South-Ural State Medical University, Chelyabinsk, Russian Federation
Chapaevskaya Central City Hospital, Chapaevsk, Russian Federation
V. A. Baranov Republic hospital, Petrozavodsk, Russian Federation
City Clinical Hospital № 25, Novosibirsk, Russian Federation
Hospital for Veterans, Petrozavodsk, Russian Federation
Clinical Hospital RZHD Meditsyna at Samara railway station, Samara, Russian Federation
Irkutsk regional clinical hospital of Conferred Order of Merit, Irkutsk, Russian Federation
Nizhniy Novgorod City Hospital № 40, Nizhny Novgorod, Russian Federation
Order of the Red Banner of Labor City Clinical Hospital №1 of Chelyabinsk, Chelyabinsk, Russian Federation
City clinical hospital № 5 of Nizhniy Novgorod, Nizhny Novgorod, Russian Federation
Gorodetskaya Central City Hospital of Nizhniy Novgorod Region, Russian Federation
S. V. Katkov Republic hospital, Saransk, Russian Federation
Republic of Karelia City Polyclinic №1, Petrozavodsk, Russian Federation
Global Medical System clinics and hospitals, Moscow, Russian Federation
Moscow City Clinical Hospital № 4, Moscow, Russian Federation
Republican tuberculosis dispensary, Petrozavodsk, Russian Federation
Health Center of Briceni, Briceni, Moldova
City Clinical Hospital № 38 of Nizhniy Novgorod Region, Nizhny Novgorod, Russian Federation
Medical center Zimamed, Krasnodar, Russian Federation
Kemerovo regional clinical psychiatric hospital, Kemerovo, Russian Federation
Saint-Petersburg hospital for veterans, St. Petersburg, Russian Federation
Labs of the Future, Moscow, Russian Federation
Novosibirsk State Medical University, Novosibirsk, Russian Federation
Novosibirsk Regional Clinical Hospital of War Veterans №3, Novosibirsk, Russian Federation
OOO Fresenius Medical Care Kuban, Krasnodar, Russian Federation
City Clinical Hospital № 3, Nizhny Novgorod, Russian Federation
City Polyclinic №1 of Prioksky District of Nizhny Novgorod, Nizhny Novgorod, Russian Federation
Republic of Mordovia Clinical Hospital № 4, Saransk, Russian Federation
Medsi, Moscow, Russian Federation
Samara City Polyclinic № 3, Samara, Russian Federation
Kazan State Medical Academy, Kazan, Russian Federation

Eurasian Association of Therapists
Pirogov Russian National Research Medical University
Privolzhsky Research Medical University
S. Avdalbekyan National Institute of Health
I. M. Sechenov First Moscow State Medical University
Almazov National Medical Research Centre
Volgograd State Medical University
V. I. Razumovsky Saratov State Medical University
E. I. Chazov National medical research center of cardiology
Rostov State Medical University
Erebouni Cardiology Center
Nicolae Testemitanu State University of Medicine and Pharmacy
I. I. Mechnikov North-Western State Medical University
Ogarev Mordovia State University
Pavlov First St. Petersburg State Medical University
Interregional Clinical Diagnostic Center
Kazan State Medical University
Lobachevsky Nizhny Novgorod National Research State University
Samara State Medical University
V. F. Voino-Yasenetsky Krasnoyarsk state medical University
Regional Clinical Hospital
Krasnogorsk city hospital № 1
Kirovsk Interdistrict Hospital
City Hospital № 51
Republican Specialized Scientific and Practical Medical Center for Therapy and Medical Rehabilitation
Medical Center GAUZ GKB № 7
Petrozavodsk State University
Chita State Medical Academy
Kirov State Medical University
City Clinical Hospital № 13 of Nizhniy Novgorod
Irkutsk State Medical Academy of Postgraduate Education
Moscow City Clinical Hospital № 40
Gomel State Medical University
M. Mirrakhimov National Center of Cardiology and Internal Medicine
Asfendiyarov Kazakh National Medical University
E. A. Vagner Perm State Medical University
Kazakh University of Continuing Education
I. Zhekenovа Clinical Infectious Diseases Hospital
Yerevan State Medical University
Central Clinical Hospital with Polyclinic of the Office of the President of RF
Perm Regional Clinical Cardiology Dispensary
The Volga District Medical Centre
Clinical City Hospital № 1 of Kishinev
Polyclinic № 1 Polyclinic of the Office of the President of RF
Perm Regional Clinical Hospital
South-Ural State Medical University
Chapaevskaya Central City Hospital
V. A. Baranov Republic hospital
City Clinical Hospital № 25
Hospital for Veterans
Clinical Hospital RZHD Meditsyna at Samara railway station
Irkutsk regional clinical hospital of Conferred Order of Merit
Nizhniy Novgorod City Hospital № 40
Order of the Red Banner of Labor City Clinical Hospital №1 of Chelyabinsk
City clinical hospital № 5 of Nizhniy Novgorod
Gorodetskaya Central City Hospital of Nizhniy Novgorod Region
S. V. Katkov Republic hospital
Republic of Karelia City Polyclinic №1
Global Medical System clinics and hospitals
Moscow City Clinical Hospital № 4
Republican tuberculosis dispensary
Health Center of Briceni
City Clinical Hospital № 38 of Nizhniy Novgorod Region
Medical center Zimamed
Kemerovo regional clinical psychiatric hospital
Saint-Petersburg hospital for veterans
Labs of the Future
Novosibirsk State Medical University
Novosibirsk Regional Clinical Hospital of War Veterans №3
OOO Fresenius Medical Care Kuban
City Clinical Hospital № 3
City Polyclinic №1 of Prioksky District of Nizhny Novgorod
Republic of Mordovia Clinical Hospital № 4
Medsi
Samara City Polyclinic № 3
Kazan State Medical Academy

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