ACTIV SARS-CoV-2 registry (Analysis of Chronic Non-infectious Diseases Dynamics after COVID-19 Infection in Adult Patients). Assessment of impact of combined original comorbid diseases in patients with COVID-19 on the prognosis
Регистр «Анализ динамики Коморбидных заболеваний у пациенТов, перенесшИх инфицироВание SARS-CoV-2» (АКТИВ). Оценка влияния комбинаций исходных сопутствующих заболеваний у пациентов с COVID-19 на прогноз
Arutyunov G.P. Tarlovskaya E.I. Arutyunov A.G. Belenkov Y.N. Konradi A.O. Lopatin Y.M. Rebrov A.P. Tereshchenko S.N. Chesnikova A.I. Hayrapetyan H.G. Babin A.P. Bakulin I.G. Bakulina N.V. Balykova L.A. Blagonravova A.S. Boldina M.V. Vaisberg A.R. Galyavich A.S. Gomonova V.V. Grigoreva N.Iu. Gubareva I.V. Demko I.V. Evzerikhina A.V. Zharkov A.V. Kamilova U.K. Kim Z.F. Kuznetsova T.Yu. Lareva N.V. Makarova E.V. Malchikova S.V. Nedogoda S.V. Petrova M.M. Pochinka I.G. Protasov K.V. Protsenko D.N. Ruzanau D.Yu. Sayganov S.A. Sarybaev A.Sh. Selezneva N.M. Sugraliev A.B. Fomin I.V. Khlynova O.V. Chizhova O.Yu. Shaposhnik I.I. Shchukarev D.A. Abdrahmanova A.K. Avetisian S.A. Avoyan H.G. Azarian K.K. Aimakhanova G.T. Ayipova D.A. Akunov A.Ch. Alieva M.K. Aparkina A.V. Aruslanova O.R. Ashina E.Yu. Badina O.Yu. Barisheva O.Yu. Batchayeva A.S. Bitieva A.M. Bikhteyev I.U. Borodulina N.A. Bragin M.V. Budu A.M. Bykova G.A. Vagapova K.R. Varlamova D.D. Vezikova N.N. Verbitskaya E.A. Vilkova O.E. Vinnikova E.A. Vustina V.V. Galova E.A. Genkel V.V. Gorshenina E.I. Gostishchev R.V. Grigorieva E.V. Gubareva E.Yu. Dabylova G.M. Demchenko A.I. Dolgikh O.Yu. Duyshobayev M.Y. Evdokimov D.S. Egorova K.E. Ermilova A.N. Zheldybayeva A.E. Zarechnova N.V. Zimina Y.D. Ivanova S.Yu. Ivanchenko E.Yu. Ilina M.V. Kazakovtseva M.V. Kazymova E.V. Kalinina Y.S. Kamardina N.A. Karachenova A.M. Karetnikov I.A. Karoli N.A. Karsiev M.Kh. Kaskaeva D.S. Kasymova K.F. Kerimbekova Z.B. Kerimova A.Sh. Kim E.S. Kiseleva N.V. Klimenko D.A. Klimova A.V. Kovalishena O.V. Kolmakova E.V. Kolchinskaya T.P. Kolyadich M.I. Kondriakova O.V. Konoval M.P. Konstantinov D.Yu. Konstantinova E.A. Kordukova V.A. Koroleva E.V. Kraposhina A.Yu. Kriukova T.V. Kuznetsova A.S. Kuzmina T.Yu. Kuzmichev K.V. Kulchoroeva C.K. Kuprina T.V. Kouranova I.M. Kurenkova L.V. Kurchugina N.Yu. Kushubakova N.A. Levankova V.I. Lyubavina N.A. Magdeyeva N.A. Mazalov K.V. Maiseenka V.I. Makarova A.S. Maripov A.M. Marusina A.A. Melnikov E.S. Moiseenko N.B. Muradova F.N. Muradyan R.G. Musaelian S.N. Myshak A.O. Nekaeva E.S. Nikitina N.M. Ogurlieva B.B. Odegova A.A. Omarova Y.M. Omurzakova N.A. Ospanova S.O. Pahomova E.V. Petrov L.D. Plastinina S.S. Pogrebetskaya V.A. Polyakov D.S. Ponomarenko E.V. Popova L.L. Prokofeva N.A. Pudova I.A. Rakov N.A. Rakhimov A.N. Rozanova N.A. Serikbolkyzy S. Simonov A.A. Skachkova V.V. Soloveva D.V. Soloveva I.A. Subbotin A.K. Sukhomlinova I.M. Sushilova A.G. Tagayeva D.R. Titojkina Y.V. Tikhonova E.P. Tokmin D.S. Tolmacheva A.A. Torgunakova M.S. Trenogina K.V. Trostianetckaia N.A. Trofimov D.A. Tulichev A.A. Tursunova A.T. Ulanova N.D. Fatenkov O.V. Fedorishina O.V. Fil T.S. Fomina I.Yu. Fominova I.S. Frolova I.A. Tsvinger S.M. Tsoma V.V. Cholponbaeva M.B. Chudinovskikh T.I. Shevchenko O.A. Sheshina T.V. Shishkina E.A. Shishkov K.Yu. Sherbakov S.Yu. Yausheva E.A.
2022Consilium Medikum
Terapevticheskii Arkhiv
2022#94Issue 132 - 47 pp.
Aim. Study the impact of various combinations of comorbid original diseases in patients infected with COVID-19 later on the disease progression and outcomes of the new coronavirus infection. Materials and methods. The ACTIV registry was created on the Eurasian Association of Therapists’ initiative. 5,808 patients have been included in the registry: men and women with COVID-19 treated at hospital or at home. ClinicalTrials.gov ID NCT04492384. Results. Most patients with COVID-19 have original comorbid diseases (oCDs). Polymorbidity assessed by way of simple counting of oCDs is an independent factor in negative outcomes of COVID-19. Search for most frequent combinations of 2, 3 and 4 oCDs has revealed absolute domination of cardiovascular diseases (all possible variants). The most unfavorable combination of 2 oCDs includes atrial hypertension (AH) and chronic heart failure (CHF). The most unfavorable combination of 3 oCDs includes AH, coronary heart disease (CHD) and CHF; the worst combination of 4 oCDs includes AH, CHD, CHF and diabetes mellitus. Such combinations increased the risk of lethal outcomes 3.963, 4.082 and 4.215 times respectively. Conclusion. Polymorbidity determined by way of simple counting of diseases may be estimated as a factor in the lethal outcome risk in the acute phase of COVID-19 in real practice. Most frequent combinations of 2, 3 and 4 diseases in patients with COVID-19 primarily include cardiovascular diseases (AH, CHD and CHF), diabetes mellitus and obesity. Combinations of such diseases increase the COVID-19 lethal outcome risk.
ACTIV registry , cardiovascular diseases , COVID-19 , diabetes mellitus , disease combinations , polymorbidity
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Eurasian Association of Therapists, Moscow, Russian Federation
Pirogov Russian National Research Medical University, Moscow, Russian Federation
Privolzhsky Research Medical University, Nizhnii Novgorod, Russian Federation
Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation
Almazov National Medical Research Centre, Saint Petersburg, Russian Federation
Volgograd State Medical University, Volgograd, Russian Federation
Razumovsky Saratov State Medical University, Saratov, Russian Federation
National Medical Research Center of Cardiology, Moscow, Russian Federation
Rostov State Medical University, Rostov-on-Don, Russian Federation
Erebouni Cardiology Center, Yerevan, Armenia
Nicolae Testemitanu State University of Medicine and Pharmacy, Chisinau, Moldova
Mechnikov North-Western State Medical University, Saint Petersburg, Russian Federation
Ogarev Mordovia State University, Saransk, Russian Federation
Republican Center for Cardiovascular Diseases of Interregional Clinical Diagnostic Center, Kazan, Russian Federation
Kazan State Medical University, Kazan, Russian Federation
Lobachevsky State University, Nizhnii Novgorod, Russian Federation
Samara State Medical University, Samara, Russian Federation
Regional Clinical Hospital, Krasnoiarsk, Russian Federation
Krasnogorsk City Hospital №1, Krasnogorsk, Russian Federation
Kirovsk Interdisrict Hospital, Kirovsk, Russian Federation
Republican Specialized Scientific and Practical Medical Center for Therapy and Medical Rehabilitation, Tashkent, Uzbekistan
City Clinical Hospital №7, Kazan, Russian Federation
Petrozavodsk State University, Petrozavodsk, Russian Federation
Chita State Medical Academy, Chita, Russian Federation
Kirov State Medical University, Kirov, Russian Federation
Voino-Yasenetsky Krasnoyarsk State Medical University, Krasnoiarsk, Russian Federation
City Clinical Hospital №13 of Nizhnii, Novgorod, Russian Federation
Irkutsk State Medical Academy of Postgraduate Education, Branch of Russian Medical Academy of Continuous Professional Education, Irkutsk, Russian Federation
Moscow City Clinical Hospital №40, Moscow, Russian Federation
Gomel State Medical University, Gomel, Belarus
Mirrakhimov National Center of Cardiology and Therapy, Bishkek, Kyrgyzstan
Asfendiyarov Kazakh National Medical University, Almaty, Kazakhstan
Vagner Perm State Medical University, Perm, Russian Federation
South Ural State Medical University, Chelyabinsk, Russian Federation
Kazakh Medical University of Continuing Education, Almaty, Kazakhstan
Zhekenovа City Clinical Infectious Diseases Hospital, Almaty, Kazakhstan
Clinical Cardiological Dispensary, Perm, Russian Federation
Volga District Medical Centre, Nizhnii Novgorod, Russian Federation
City Clinical Hospital №1, Chisinau, Moldova
Polyclinic №1 of the President of the Russian Federation, Moscow, Russian Federation
Perm Regional Clinical Hospital, Perm, Russian Federation
Chapaevskaya Central City Hospital, Chapaevsk, Russian Federation
Baranov Republic Hospital, Petrozavodsk, Russian Federation
Serbsky National Medical Research Centre for Psychiatry and Narcology, Moscow, Russian Federation
City Clinical Hospital №25, Novosibirsk, Russian Federation
Hospital for Veterans, Petrozavodsk, Russian Federation
Polyclinic of Kirovsk Interdistrict Hospital, Kirovsk, Russian Federation
Clinical Hospital RZhD Meditsyna, Samara, Russian Federation
Irkutsk Regional Сlinical Рospital, Irkutsk, Russian Federation
City Hospital №134, Moscow, Russian Federation
City Clinical Hospital №1, Chelyabinsk, Russian Federation
City Сlinical Рospital №5, Nizhnii Novgorod, Russian Federation
Gorodetskaya Central District Hospital, Nizhnii Novgorod, Russian Federation
Katkov Republic Clinical Hospital, Saransk, Russian Federation
City Polyclinic №1, Petrozavodsk, Russian Federation
Global Medical System Clinics and Hospitals, Moscow, Russian Federation
Yerevan State Medical University, Yerevan, Armenia
Group of companies Medinvestgroup, Moscow, Russian Federation
Moscow City Clinical Hospital №4, Moscow, Russian Federation
Republican Tuberculosis Dispensary, Syktyvkar, Russian Federation
Health Center of Brichen, Briceni, Moldova
City Clinical Hospital №38, Nizhnii Novgorod, Russian Federation
Medical center Zimamed, Krasnodar, Russian Federation
City Polyclinic №4, Nizhnii Novgorod, Russian Federation
Hospital for Veterans, Saint Petersburg, Russian Federation
Labs of the Future, Moscow, Russian Federation
Novosibirsk State Medical University, Novosibirsk, Russian Federation
Clinical Counselling and Diagnostic Polyclinic, Novosibirsk, Russian Federation
City Clincal Hospital №3, Nizhnii Novgorod, Russian Federation
City Polyclinic №1, Nizhnii Novgorod, Russian Federation
Samara City Polyclinic №3, Samara, Russian Federation
Kazan State Medical Academy, Branch of the Russian Medical Academy of Continuous Professional Education, Kazan, Russian Federation
Eurasian Association of Therapists
Pirogov Russian National Research Medical University
Privolzhsky Research Medical University
Sechenov First Moscow State Medical University (Sechenov University)
Almazov National Medical Research Centre
Volgograd State Medical University
Razumovsky Saratov State Medical University
National Medical Research Center of Cardiology
Rostov State Medical University
Erebouni Cardiology Center
Nicolae Testemitanu State University of Medicine and Pharmacy
Mechnikov North-Western State Medical University
Ogarev Mordovia State University
Republican Center for Cardiovascular Diseases of Interregional Clinical Diagnostic Center
Kazan State Medical University
Lobachevsky State University
Samara State Medical University
Regional Clinical Hospital
Krasnogorsk City Hospital №1
Kirovsk Interdisrict Hospital
Republican Specialized Scientific and Practical Medical Center for Therapy and Medical Rehabilitation
City Clinical Hospital №7
Petrozavodsk State University
Chita State Medical Academy
Kirov State Medical University
Voino-Yasenetsky Krasnoyarsk State Medical University
City Clinical Hospital №13 of Nizhnii
Irkutsk State Medical Academy of Postgraduate Education
Moscow City Clinical Hospital №40
Gomel State Medical University
Mirrakhimov National Center of Cardiology and Therapy
Asfendiyarov Kazakh National Medical University
Vagner Perm State Medical University
South Ural State Medical University
Kazakh Medical University of Continuing Education
Zhekenovа City Clinical Infectious Diseases Hospital
Clinical Cardiological Dispensary
Volga District Medical Centre
City Clinical Hospital №1
Polyclinic №1 of the President of the Russian Federation
Perm Regional Clinical Hospital
Chapaevskaya Central City Hospital
Baranov Republic Hospital
Serbsky National Medical Research Centre for Psychiatry and Narcology
City Clinical Hospital №25
Hospital for Veterans
Polyclinic of Kirovsk Interdistrict Hospital
Clinical Hospital RZhD Meditsyna
Irkutsk Regional Сlinical Рospital
City Hospital №134
City Clinical Hospital №1
City Сlinical Рospital №5
Gorodetskaya Central District Hospital
Katkov Republic Clinical Hospital
City Polyclinic №1
Global Medical System Clinics and Hospitals
Yerevan State Medical University
Group of companies Medinvestgroup
Moscow City Clinical Hospital №4
Republican Tuberculosis Dispensary
Health Center of Brichen
City Clinical Hospital №38
Medical center Zimamed
City Polyclinic №4
Hospital for Veterans
Labs of the Future
Novosibirsk State Medical University
Clinical Counselling and Diagnostic Polyclinic
City Clincal Hospital №3
City Polyclinic №1
Samara City Polyclinic №3
Kazan State Medical Academy
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