Peripheral blood lymphocytes apoptosis role in rheumatoid arthritis progressing
Aringazina R. Seitmaganbetova N. Mussina A. Zame Y. Saparbayev S. Zholdassova N. Kaibagarova I.
2023National Scientific Medical Center
Journal of Clinical Medicine of Kazakhstan
2023#20Issue 44 - 9 pp.
Rheumatoid arthritis (RA) is an autoimmune, chronic, and genetically linked inflammatory lesion of joint tissues that is accompanied by extra-articular systemic pathologies. The disease progression leads to joints immobilization, and eventually, the patients disability occurs approximately ten years from the first clinical manifestation. RA pathogenesis involves various mechanisms: specific joint-related damage, nonspecific adaptive, and vessel-related pathological changes. Our research aimed to study the role of peripheral blood lymphocyte apoptosis in RA pathogenesis. We have analyzed research data from Google Scholar, PubMed, Web of Science, and Scopus databases to investigate the role of lymphocyte apoptosis in RA progression. Clinical manifestations in RA are caused by autoreactive T-and B-lymphocyte activity supported by humoral and cellular immune factors activity. Disease pathogenesis is caused by an imbalance in the process of programmed cell death (apoptosis): a proportion of immune cells are rapidly destroyed. In contrast, apoptosis is inhibited in the other classes of immune cells. High infiltration of the joint by autoreactive sensitized lymphocytes worsens the patients condition. Apoptosis inhibition is especially noticeable in the early stages of RA and correlates with the concentration of the anti-apoptotic molecule Bcl-2 in the synovia. Activating the apoptotic destruction of lymphocytes (by drug action) allows a positive therapeutic effect and sustained remission. However, it should be noted that genetic factors play a significant role in the onset, progression and drug response of RA. In addition, environmental and behavioral factors can activate RA progression and influence treatment efficacy.
apoptosis , blood serum , genetic factors , joint , lymphocytes , pathogenesis , rheumatoid arthritis , treatment
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Department of Internal Diseases No1, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan
Department of Propedeutics of Internal Diseases, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan
Department of Clinical Pharmacology, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan
Department of Childrens Diseases No 1 with Neonatology, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan
Department for Scientific Work, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan
Department of Therapeutic and Orthopaedic Dentistry, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan
Department of Internal Diseases No1
Department of Propedeutics of Internal Diseases
Department of Clinical Pharmacology
Department of Childrens Diseases No 1 with Neonatology
Department for Scientific Work
Department of Therapeutic and Orthopaedic Dentistry
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