Untapped potential of wild medicinal flora: HPLC-based characterization, enzyme inhibition and antioxidant properties of Macrochloa tenacissima (L.) kunth and Sinapis arvensis extracts
Arabi R. Chafaa M. Arabi Z. Çakir C. Öztürk M. Taha T.H. Boufahja F. Bendif H. Garzoli S.
2025Taylor and Francis Ltd.
Natural Product Research
2025
This study investigated the chemical composition and biological activities of Macrochloa tenacissima and Sinapis arvensis using HPLC-DAD and in vitro assays. HPLC analysis revealed that M. tenacissima flowers contained apigenin (1.15 mg/g), luteolin (0.74 mg/g) and epicatechin (0.52 mg/g), along with traces of theobromine, theophylline and coumarins, whereas S. arvensis was rich in caffeic (0.80 mg/g) and ferulic acids (0.09 mg/g). Antioxidant assays demonstrated that methanol extracts of M. tenacissima exhibited strong DPPH (148.45 ± 5.88 µg/mL) and ABTS (50.44 ± 5.94 µg/mL) scavenging, while S. arvensis showed the highest cupric reducing power (138.61 ± 3.17 µg/mL). Enzyme inhibition assays indicated that M. tenacissima exerted the strongest butyrylcholinesterase (446.92 ±23.96 µg/mL) and tyrosinase inhibition (693.57 µg/mL). These findings, representing the first report on M. tenacissima bioactivities, highlight the pharmacological potential of both species as valuable sources of natural antioxidants and enzyme inhibitors.
antioxidant power , enzyme inhibitory effect , HPLC-DAD , Macrochloa tenacissima (L.) kunth , S. arvensis L
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Laboratory of Agro-Biotechnology and Nutrition in Semi-arid Areas, Faculty of Nature and Life Sciences, University Ibn Khaldoun, Tiaret, Algeria
Faculty of Nature and Life Sciences, University Ibn Khaldoun, Tiaret, Algeria
Department of Chemistry, Faculty of Sciences, Muğla Sitki Kocman University, Muğla, Turkey
Faculty of Chemistry and Chemical Technology, Al-Farabi Kazakh National University, Almaty, Kazakhstan
Biology Department, College of Science, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, Saudi Arabia
Department of Chemistry and Technologies of Drug, Sapienza University, Rome, Italy
Laboratory of Agro-Biotechnology and Nutrition in Semi-arid Areas
Faculty of Nature and Life Sciences
Department of Chemistry
Faculty of Chemistry and Chemical Technology
Biology Department
Department of Chemistry and Technologies of Drug
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