Patient phenotype profiling in heart failure with preserved ejection fraction to guide therapeutic decision making. A scientific statement of the Heart Failure Association, the European Heart Rhythm Association of the European Society of Cardiology, and the European Society of Hypertension
Anker S.D. Usman M.S. Anker M.S. Butler J. Böhm M. Abraham W.T. Adamo M. Chopra V.K. Cicoira M. Cosentino F. Filippatos G. Jankowska E.A. Lund L.H. Moura B. Mullens W. Pieske B. Ponikowski P. Gonzalez-Juanatey J.R. Rakisheva A. Savarese G. Seferovic P. Teerlink J.R. Tschöpe C. Volterrani M. von Haehling S. Zhang J. Zhang Y. Bauersachs J. Landmesser U. Zieroth S. Tsioufis K. Bayes-Genis A. Chioncel O. Andreotti F. Agabiti-Rosei E. Merino J.L. Metra M. Coats A.J.S. Rosano G.M.C.
July 2023John Wiley and Sons Ltd
European Journal of Heart Failure
2023#25Issue 7936 - 955 pp.
Heart failure with preserved ejection fraction (HFpEF) represents a highly heterogeneous clinical syndrome affected in its development and progression by many comorbidities. The left ventricular diastolic dysfunction may be a manifestation of various combinations of cardiovascular, metabolic, pulmonary, renal, and geriatric conditions. Thus, in addition to treatment with sodium–glucose cotransporter 2 inhibitors in all patients, the most effective method of improving clinical outcomes may be therapy tailored to each patients clinical profile. To better outline a phenotype-based approach for the treatment of HFpEF, in this joint position paper, the Heart Failure Association of the European Society of Cardiology, the European Heart Rhythm Association and the European Hypertension Society, have developed an algorithm to identify the most common HFpEF phenotypes and identify the evidence-based treatment strategy for each, while taking into account the complexities of multiple comorbidities and polypharmacy.
Heart failure , Heart failure with preserved ejection fraction , Phenotype
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Department of Cardiology, Deutsches Herzzentrum der Charité, Berlin Institute of Health Center for Regenerative Therapies (BCRT), and German Centre for Cardiovascular Research (DZHK) partner site Berlin, Charité Universitätsmedizin, Campus CVK, Berlin, Germany
Department of Medicine, University of Mississippi Medical Center, Jackson, MS, United States
Deutsches Herzzentrum der Charité, Klinik fär Kardiologie, Angiologie und Intensivmedizin, Berlin Institute of Health Center for Regenerative Therapies (BCRT), and German Centre for Cardiovascular Research (DZHK) partner site Berlin, Charité Universitätsmedizin Berlin, Campus CBF, Berlin, Germany
Baylor Scott and White Research Institute, Dallas, TX, United States
Klinik für Innere Medizin III, Universitätsklinikum des Saarlandes, Saarland University, Homburg, Germany
Ohio State University Wexner Medical Center, Columbus, OH, United States
Cardiology, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Brescia, Italy
Max Superspeciality Hospital, New Delhi, India
Division of Cardiology, Magalini Hospital, Verona, Italy
Department of Medicine, Karolinska Institutet, and Heart and Vascular Theme, Karolinska University Hospital, Stockholm, Sweden
National and Kapodistrian University of Athens, School of Medicine, Athens, Greece
Institute of Heart Diseases, Wroclaw Medical University, Wroclaw, Poland
Centro de Investigação em Tecnologias e Serviços de Saúde, Porto, Portugal; Serviço de Cardiologia, Hospital das Forças Armadas-Pólo do Porto, Porto, Portugal
Department of Cardiology, Ziekenhuis Oost Limburg, Genk and Faculty of Medicine and Life Sciences, University Hasselt, Belgium
Berlin-Brandenburgische Gesellschaft für Herz-Kreislauferkrankungen (BBGK), Berlin, Germany
Cardiology Department, Wroclaw Medical University, Wroclaw, Poland
Cardiology Department, Hospital Clínico Universitario, Santiago de Compostela, IDIS, CIBERCV, Santiago de Compostela, Spain
Department of Cardiology, Scientific Institution of Cardiology and Internal Diseases, Almaty, Kazakhstan
Department Faculty of Medicine, University of Belgrade, Belgrade & Serbian Academy of Sciences and Arts, Belgrade, Serbia
Section of Cardiology, San Francisco Veterans Affairs Medical Center and School of Medicine, University of California, San Francisco, CA, United States
Department of Cardiology, Angiology and Intensive Care Medicine (CVK), Charité Universitätsmedizin, Berlin, Germany
Cardio-Pulmonary Department, San Raffaele Open University of Rome; Exercise Science and Medicine, IRCCS San Raffaele – Rome, Italy
Department of Cardiology, University Medcine Göttingen, Göttingen, Germany
Fuwai Hospital Chinese Academic of Medical Science, Beijing, China
Department of Cardiology and Angiology, Hannover Medical School, Hannover, Germany
Berlin Institute of Health at Charité, Berlin, Germany
Section of Cardiology, Max Rady College of Medicine, University of Manitoba Winnipeg, Winnipeg, MB, Canada
1st Department of Cardiology, National and Kapodistrian University of Athens, Athens, Greece
Heart Institute, Hospital Universitari Germans Trias i Pujol, Badalona, CIBERCV, Barcelona, Spain
Emergency Institute for Cardiovascular Diseases ‘Prof. C.C. Iliescu’, University of Medicine Carol Davila, Bucharest, Romania
Fondazione Policlinico Universitario Gemelli IRCCS, Rome, Italy
Catholic University Medical School, Rome, Italy
Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy
Department of Cardiology, La Paz University Hospital, IdiPaz, Universidad Autonoma, Madrid, Spain
Heart Research Institute, Newtown, NSW, Australia
Department of Cardiology
Department of Medicine
Deutsches Herzzentrum der Charité
Baylor Scott and White Research Institute
Klinik für Innere Medizin III
Ohio State University Wexner Medical Center
Cardiology
Max Superspeciality Hospital
Division of Cardiology
Department of Medicine
National and Kapodistrian University of Athens
Institute of Heart Diseases
Centro de Investigação em Tecnologias e Serviços de Saúde
Department of Cardiology
Berlin-Brandenburgische Gesellschaft für Herz-Kreislauferkrankungen (BBGK)
Cardiology Department
Cardiology Department
Department of Cardiology
Department Faculty of Medicine
Section of Cardiology
Department of Cardiology
Cardio-Pulmonary Department
Department of Cardiology
Fuwai Hospital Chinese Academic of Medical Science
Department of Cardiology and Angiology
Berlin Institute of Health at Charité
Section of Cardiology
1st Department of Cardiology
Heart Institute
Emergency Institute for Cardiovascular Diseases ‘Prof. C.C. Iliescu’
Fondazione Policlinico Universitario Gemelli IRCCS
Catholic University Medical School
Department of Clinical and Experimental Sciences
Department of Cardiology
Heart Research Institute
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