Modification of Biocorrosion and Cellular Response of Magnesium Alloy WE43 by Multiaxial Deformation
Anisimova N. Martynenko N. Novruzov K. Rybalchenko O. Kiselevskiy M. Rybalchenko G. Straumal B. Salishchev G. Mansharipova A. Kabiyeva A. Gabdullin M. Dobatkin S. Estrin Y.
January 2022MDPI
Metals
2022#12Issue 1
The study shows that multiaxial deformation (MAD) treatment leads to grain refinement in magnesium alloy WE43. Compared to the initial state, the MAD-processed alloy exhibited smoother biocorrosion dynamics in a fetal bovine serum and in a complete cell growth medium. Examination by microCT demonstrated retardation of the decline in the alloy volume and the Hounsfield unit values. An attendant reduction in the rate of accumulation of the biodegradation products in the immersion medium, a less pronounced alkalization, and inhibited sedimentation of biodegradation products on the surface of the alloy were observed after MAD. These effects were accompanied with an increase in the osteogenic mesenchymal stromal cell viability on the alloy surface and in a medium containing their extracts. It is expected that the more orderly dynamics of biodegradation of the WE43 alloy after MAD and the stimulation of cell colonization will effectively promote stable osteosynthesis, making repeat implant extraction surgeries unnecessary.
Biodegradation , Cell colonization , Cell viability , Magnesium alloy , Multiaxial deformation
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N.N. Blokhin National Medical Research Center of Oncology of the Ministry of Health of the Russian, Federation (N.N. Blokhin NMRCO), Moscow, 115478, Russian Federation
Department of Physical Metallurgy and the Physics of Strength, National University of Science and, Technology “MISIS”, Moscow, 119991, Russian Federation
A.A. Baikov Institute of Metallurgy and Materials Science of the RAS, Moscow, 119334, Russian Federation
P.N. Lebedev Physical Institute of the RAS, Moscow, 142432, Russian Federation
Institute of Nanotechnology, Karlsruhe Institute of Technology, Eggenstein-Leopoldshafen, 76344, Germany
Institute of Solid State Physics and Chernogolovka Scientific Center of the Russian Academy of Sciences, Chernogolovka, 142432, Russian Federation
Laboratory of Bulk Nanostructured Materials, Belgorod National Research University, Belgorod, 308015, Russian Federation
Department of Scientific and Clinical Work, Kazakh-Russian Medical University, Almaty, 050000, Kazakhstan
Association of Early Career Doctors of Almaty, Almaty, 050000, Kazakhstan
Kazakh British Technical University, Almaty, 050000, Kazakhstan
Department of Materials Science and Engineering, Monash University, Clayton, 3800, VIC, Australia
Department of Mechanical Engineering, The University of Western Australia, Perth, 6009, WA, Australia
N.N. Blokhin National Medical Research Center of Oncology of the Ministry of Health of the Russian
Department of Physical Metallurgy and the Physics of Strength
A.A. Baikov Institute of Metallurgy and Materials Science of the RAS
P.N. Lebedev Physical Institute of the RAS
Institute of Nanotechnology
Institute of Solid State Physics and Chernogolovka Scientific Center of the Russian Academy of Sciences
Laboratory of Bulk Nanostructured Materials
Department of Scientific and Clinical Work
Association of Early Career Doctors of Almaty
Kazakh British Technical University
Department of Materials Science and Engineering
Department of Mechanical Engineering
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