The role of dietary factors in modulating the intensity of systemic inflammation
Andreev K.A. Skirdenko Y.P. Gorbenko A.V. Nikolaev N.A. Nelidova A.V. Kushugulova A.R. Sadykov A.M. Kozhakhmetov S.S.
2023Media Sphera Publishing Group
Profilakticheskaya Meditsina
2023#26Issue 2115 - 121 pp.
Modern lifestyle in developed countries significantly impacts the incidence of metabolic disorders and, consequently, many chronic non-communicable diseases. These disorders are often due to chronic low-intensity inflammation caused by the activation of var-ious molecular pathways, such as nuclear factor kappa B (NF-κB), mitogen-activated protein kinase (MAPk), rapamycin complex 1 (TORC1), cyclooxygenase-2 (COX-2). Numerous interventional studies have shown that lifestyle changes help reduce inflammation and improve health. It can be attributed to the concept of real-life risk modeling, as humans are constantly exposed to dietary factors in small doses and complex combinations (e.g., polyphenols, fiber, polyunsaturated fatty acids). A balanced diet, com-bined with caloric restriction, modulates molecular mechanisms such as mTOR, NRF2, IKK/JNK, and JAK/STAT, eventually leading to a significant decrease in inflammatory markers and an improvement in metabolic parameters. Healthier diets at the individual level and in public institutions can improve population health, reduce the financial burden on the healthcare system and increase society’s resilience to epidemics that mainly affect people with metabolic diseases.
chronic non-communicable diseases , CNCDs , diet , low-intensity inflammation , nutrients
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Omsk State Medical University, Omsk, Russian Federation
Nazarbayev University, Astana, Kazakhstan
Astana Bioscience Business Centre, Astana, Kazakhstan
Omsk State Medical University
Nazarbayev University
Astana Bioscience Business Centre
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