Comparative assessment of health-related quality of life with and without anticonvulsant therapy in patients with childhood epilepsy with centrotemporal spikes
An O. Nagae L.M. Aringazina A. Winesett S.P.
2021SAGE Publications Ltd
Journal of International Medical Research
2021#49Issue 8
Objective: To estimate anti-seizure medication (ASM) treatment burden and its effects on health-related quality of life (HRQOL) in new-onset childhood epilepsy with centrotemporal spikes (CECTS) using different treatment approaches in Kazakhstan. Methods: Forty-three patients were followed prospectively during 2015 to 2020 for at least 2 years. Patients were divided into three groups: (1) history of ≤3 seizures (n = 32); (2) ≥4 seizures (n = 6); (3) cerebral palsy coexisting with CECTS (n = 5). The first group was subdivided into treated (n = 8) and observed (n = 24) subgroups. The shortened Quality of Life in Childhood Epilepsy Questionnaire (QOLCE-55) was completed by parents after 6 months of follow-up. Results: At the end of the study, all children had a sustained remission from seizures for at least 2 years. Differences were identified in emotional, social, and physical subscales between patients in the low seizure frequency group. Signs of low self-esteem, anxiety, depression, limited social interaction owing to pharmacotherapy, painful medical procedures, and stigma were reasons for decreased HRQOL in the treated subgroup. Overall HRQOL in treated (89.2 ± 5.2) patients was significantly decreased compared with observed children with low seizure frequency (98.0 ± 3.0). Conclusion: ASM therapy does not necessarily improve and may decrease HRQOL in children with low seizure frequency CECTS.
anti-seizure medication , cerebral palsy , Childhood epilepsy with centrotemporal spikes , health-related quality of life , Quality of Life in Childhood Epilepsy Questionnaire-55
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Department of Children’s Diseases, Kazakhstan’s Medical University, School of Public Health (KSPH), Almaty, Kazakhstan
Department of Medical Imaging, Neuroradiology, Banner University Medical Center, Tucson, AZ, United States
Department of Population Health and Social Sciences, Kazakhstan’s Medical University, School of Public Health (KSPH), Almaty, Kazakhstan
Department of Pediatrics, Division of Pediatric Neurology, University of Florida, Gainesville, FL, United States
Department of Children’s Diseases
Department of Medical Imaging
Department of Population Health and Social Sciences
Department of Pediatrics
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