The role of Tumour Necrosis Factor in neuroinflammation associated with Parkinsons disease and targeted therapies
Amin R. Quispe C. Docea A.O. Ydyrys A. Kulbayeva M. Durna Daştan S. Calina D. Sharifi-Rad J.
September 2022Elsevier Ltd
Neurochemistry International
2022#158
Neurodegenerative disorders Parkinsons disease is a progressive neurodegenerative disorder associated with neuroinflammatory responses that lead to the neurodegeneration of the dopaminergic neurons. These neuroinflammatory mechanisms involve various cytokines produced by the activated glial cells. Tumour Necrosis factor α (TNF α) is one of the major mediators of the neuroinflammation associated with neurodegeneration. TNF α has a dual role of neuroprotection and neurotoxicity in the brain. The effective pathways of TNF involve various signalling pathways transduced by the receptors TNFR1 and TNFR2. Effective therapeutic strategies have been produced targeting the neurotoxic behaviour of the Tumour Necrosis Factor and the associated neurodegeneration which includes the use of Dominant Negative Tumour Necrosis Factor (DN-TNF) inhibitors like XENP 345 and XPro®1595 and peroxisome proliferator receptor gamma (PPAR-γ) agonists.
Inflammation , Microglia , Neurodegeneration , Neuroinflammation , Parkinsons disease , TNF-α , TNF-α inhibitors
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Faculty of Pharmaceutical Science, Assam Down Town University, Panikhaiti, Guwahati, Assam, India
Facultad de Ciencias de la Salud, Universidad Arturo Prat, Avda. Arturo Prat 2120, Iquique, 1110939, Chile
Department of Toxicology, University of Medicine and Pharmacy of Craiova, Craiova, 200349, Romania
Biomedical Research Centre, Al-Farabi Kazakh National University, Al-Farabi av. 71, Almaty, 050040, Kazakhstan
Department of Biophysics, Biomedicine and Neuroscience, Al-Farabi Kazakh National University, Al-Farabi av. 71, Almaty, 050040, Kazakhstan
Department of Biology, Faculty of Science, Sivas Cumhuriyet University, Sivas, 58140, Turkey
Beekeeping Development Application and Research Center, Sivas Cumhuriyet University, Sivas, 58140, Turkey
Department of Clinical Pharmacy, University of Medicine and Pharmacy of Craiova, Craiova, 200349, Romania
Facultad de Medicina, Universidad Del Azuay, Cuenca, Ecuador
Faculty of Pharmaceutical Science
Facultad de Ciencias de la Salud
Department of Toxicology
Biomedical Research Centre
Department of Biophysics
Department of Biology
Beekeeping Development Application and Research Center
Department of Clinical Pharmacy
Facultad de Medicina
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