Vitamin D and habitual miscarriage: A case-control study
Amanzholkyzy А. Saparbayev S.S. Turesheva A. Shangaraeva A.
2025Kaz Med Print LLP
Reproductive Medicine (Central Asia)
2025#2025Issue 195 - 101 pp.
Relevance: Vitamin D plays an important role in a woman’s reproductive health, and its deficiency may be among the factors that lead to habitual miscarriage. Vitamin D is not just a vitamin but rather a hormone that plays a key role in many body processes. In addition to the traditionally known role in strengthening bone tissue, it is actively involved in a wide variety of body processes, from the functioning of the nervous system to maintaining immunity and reproductive function. The study aimed to assess the level of vitamin D in women with recurrent miscarriage in comparison with healthy women to identify possible pathophysiological relationships and determine its role in reproductive health. Methods: The study involved 130 women who were divided into two groups. The case group included 65 women with two or more spontaneous miscarriages or a non-developing pregnancy before 22 weeks of gestational age, and the control group included 65 women with a history of two or more normal births. Results: This study revealed inadequate vitamin levels in both groups. Vitamin D levels were below the reference values in women at risk of miscarriage but still higher than in women without miscarriage who were deficient in vitamin D. Conclusion: The study results showed that low vitamin D levels can increase the risk of spontaneous abortion in both women with habitual miscarriage and healthy women.
habitual miscarriage , spontaneous abortion , Vitamin D , women of reproductive age
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West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan
Al-Zhami Medical Center, Astana, Kazakhstan
Aliya Medical Center, Aktobe, Kazakhstan
West Kazakhstan Marat Ospanov Medical University
Al-Zhami Medical Center
Aliya Medical Center
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