Colorectal Cancer Screening with Computed Tomography Colonography: Single Region Experience in Kazakhstan
Amankulov J. Kaidarova D. Zholdybay Z. Zagurovskaya M. Baltabekov N. Gabdullina M. Ainakulova A. Toleshbayev D. Panina A. Satbayeva E. Kalieva Z.
January 2022Korean Society of Gastrointestinal Endoscopy
Clinical Endoscopy
2022#55Issue 1101 - 112 pp.
Background/Aims: The aim of our study was to determine the efficacy of computed tomography colonography (CTC) in screening for colorectal cancer (CRC). Methods: A total of 612 females and 588 males aged 45 to 75 years were enrolled in CTC screening. CTC was performed following standard bowel preparation and colonic insufflation with carbon dioxide. The main outcomes were the detection rate of CRC and advanced adenoma (AA), prevalence of colorectal lesions in relation to socio-demographic and health factors, and overall diagnostic performance of CTC. Results: Overall, 56.5% of the 1,200 invited subjects underwent CTC screening. The sensitivity for CRC and AA was 0.89 and 0.97, respectively, while the specificity was 0.71 and 0.99, respectively. The prevalence of CRC and AA was 3.0% (18/593) and 7.1% (42/593), respectively, with the highest CRC prevalence in the 66-75 age group (≥12 times; odds ratio [OR], 12.11; 95% confidence interval [CI], 4.45-32.92). CRC and AA prevalence were inversely correlated with Asian descent, physical activity, and negative fecal immunochemical test results (OR=0.43; 95% CI, 0.22-0.83; OR=0.16; 95% CI, 0.04-0.68; OR=0.5; 95% CI, 0.07-3.85, respectively). Conclusions: Our study revealed high accuracy of CTC in diagnosing colonic neoplasms, good compliance with CTC screening, and high detection rate of CRC.
Cancer screening , Colonoscopy , Colorectal neoplasms , Computed tomography colonography
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Department of Radiology and Nuclear Medicine, Kazakh Institute of Oncology and Radiology, Almaty, Kazakhstan
Department of Visual Diagnostics, Asfendiyarov Kazakh National Medical University, Almaty, Kazakhstan
Department of Medical Oncology, Kazakh Institute of Oncology and Radiology, Almaty, Kazakhstan
Department of Radiology, Medical College, University of Kentucky, Lexington, KY, United States
Center of Morphological Diagnostics, Kazakh Institute of Oncology and Radiology, Almaty, Kazakhstan
Department of Endoscopy, Kazakh Institute of Oncology and Radiology, Almaty, Kazakhstan
Department of Radiology and Nuclear Medicine
Department of Visual Diagnostics
Department of Medical Oncology
Department of Radiology
Center of Morphological Diagnostics
Department of Endoscopy
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