Case-Control Study of the Association between Single Nucleotide Polymorphisms of Genes Involved in Xenobiotic Detoxification and Antioxidant Protection with the Long-Term Influence of Organochlorine Pesticides on the Population of the Almaty Region
Altynova N. Khamdiyeva O. Garshin A. Baratzhanova G. Amirgaliyeva A. Seisenbayeva A. Abylkassymova G. Yergali K. Tolebaeva A. Skvortsova L. Zhunussova G. Bekmanov B. Cakir-Kiefer C. Djansugurova L.
December 2023Multidisciplinary Digital Publishing Institute (MDPI)
Toxics
2023#11Issue 12
The association of genetic polymorphisms with the individual sensitivity of humans to the action of pesticide pollution is being actively studied in the world. The aim of this study was a molecular epidemiological analysis of candidate polymorphisms of genes involved in pesticide metabolism, detoxification, and antioxidant protection. Some of the selected polymorphisms also relate to susceptibility to cancer and cardiovascular, respiratory, and immune system diseases in individuals exposed to pesticides for a long time. For a case-control study of a unique cohort of people exposed to organochlorine pesticides for 10 years or more were chosen, a control cohort was selected that matched with the experimental group by the main population characteristics. PCR-PRLF and genome-wide microarray genotyping (GWAS) methods were used. We identified 17 polymorphisms of xenobiotic detoxification genes and 27 polymorphisms of antioxidant defense genes, which had a significantly high statistical association with the negative impact of chronic pesticide intoxication on human health. We also found 17 polymorphisms of xenobiotic detoxification genes and 12 polymorphisms of antioxidant defense genes that have a protective effect. Data obtained added to the list of potential polymorphisms that define a group at high risk or resistant to the negative effects of pesticides.
antioxidant protection genes , case-control study , organochlorine pesticides , pesticides , public health , SNP , xenobiotic detoxification genes
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Institute of Genetics and Physiology, Al-Farabi Avenue 93, Almaty, 050060, Kazakhstan
Faculty of Biology and Biotechnology, Al-Farabi Kazakh National University, Al-Farabi Avenue 71, Almaty, 050040, Kazakhstan
INRAE, UR AFPA, USC 340, University of Lorraine, Nancy, F-54000, France
Institute of Genetics and Physiology
Faculty of Biology and Biotechnology
INRAE
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