A genome-wide association study for different types of allergic diseases
Altynova N.K. Khamdiyeva O.K. Zhaniyazov Z.A. Garshin A.A. Baratzhanova G.S. Amirgaliyeva A.S. Yergali K. Artygaliyeva D.N. Talgatbekova D.Zh. Tokmurzina S.S. Abdullayeva M.S. Zhunussova G.S. Djansugurova L.B.
28 December 2022al-Farabi Kazakh State National University
International Journal of Biology and Chemistry
2022#15Issue 225 - 39 pp.
All over the world, there is an active search for genes that are responsible for the formation of predisposition to allergic diseases, which is associated both with the undoubted relevance of studying risk factors for the development of allergies, and with the emergence of new opportunities for genetic research. In addition, anthropogenic impact can cause allergic reactions and modifications in the functions of antioxidant defense cells and the immune system. Due to the fact that in the cohort of the population of Almaty and the Almaty region (going forward we will say Almaty to include the region also), respiratory diseases with an allergic component, such as bronchial asthma, bronchitis, allergic rhinitis, are common, we consider it is appropriate to conduct an epidemiological study of candidate genes for allergic diseases – cytokines and their receptors (IL4, IL4RA, IL12B, IL13, TNFA, CCL5), adrenoreceptor (ADRB2), transcription factors involved in T-lymphocyte differentiation (STAT6, GATA3, TBX21), major histocompatibility complex (HLA-DRB1, HLA-DQB1). The aim of our study is to conduct genome-wide genotyping in people with allergic diseases and to search for marker genes that affect the risk of developing allergies as well as to identify genes that are involved in the pathogenesis of allergic diseases. We performed genome-wide microarray genotyping of 25355 SNPs on the iScan platform of 103 samples with allergic diseases and 108 control DNA samples using the kit (Infinium® ImmunoArray24-v2.0 BeadChip Kit). The results obtained, using the GWAS analysis, which considers numerous polymorphisms, showed the involvement of some genes in the development of allergic diseases (rs20541-asthma, allergic rhinitis, rs841718-atopic dermatitis, rs3212227-immunodeficiency).
Allergic rhinitis (AR) , allergy , Atopic dermatitis (AD) , Bronchial asthma (BA) , GWAS-genome-wide genotyping , marker genes , single nucleotide polymorphism (SNP)
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Institute of Genetics and Physiology, Almaty, Kazakhstan
Medical center “Allergo Clinic”, Almaty, Kazakhstan
Institute of Genetics and Physiology
Medical center “Allergo Clinic”
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