IMMUNOLOGICAL CRITERIA FOR PREDICTING SEVERE AND COMPLICATED FORMS OF VARICELLA ZOSTER IN CHILDREN

Иммунологические критерии прогнозирования тяжелых и осложненных форм ветряной оспы у детей
Alshimbayeva Z.E. Begaydarova R.Kh. Khodzhaeva N.M. Alshynbekova G.K. Koichubekov B.K. Zolotaryova O.A.
January 2025 Georgian Association of Business Press

Georgian Medical News
2025 #366 Issue 9 164 - 169 pp.

Aim of the study: To evaluate immunological markers associated with the risk of severe and complicated forms of varicella zoster virus (VZ) in children in order to determine prognostic criteria for disease severity. Materials and methods: The study included 120 children with VZ, divided into groups with complicated (n=63) and uncomplicated(n=57)disease.Allpatientsunderwentassessment of interferon alpha markers, complement components (C3, C4), antibodies to MAG, TGF, as well as analysis of complete blood count and C-reactive protein (CRP). Statistical analysis included binary logistic regression and 5-fold cross-validation. Selection criteria: Children aged 0 to 18 years inclusive with a verified diagnosis of varicella Results: The most significant predictors of complicated disease were elevated levels of CRP (OR = 10.05; p < 0.001), platelets (OR = 9.69; p = 0.04), and C3 component (OR = 2.77; p = 0.006), as well as reduced levels of C4 component (OR = 0.036; p = 0.005). The logistic regression model showed high discriminatory ability (AUC = 0.7857). Conclusion: Immunological parameters such as CRP, C3, C4 and platelets can be used as prognostic markers of complicated varicella in children. Early assessment of immune status contributes to the timely identification of patients at risk and optimization of treatment tactics.

children , compliment , CRP , CРБ , immunological markers , prognosis of complications , Varicella , ветряная оспа , дети , иммунологические маркеры , комплемент

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NJSC “Karaganda Medical University”, Gogol St., 40, Karaganda, 100008, Kazakhstan
Avicenna Tajik State Medical University, Tajikistan

NJSC “Karaganda Medical University”
Avicenna Tajik State Medical University

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