Prevention of Pre-Eclampsia: Modern Strategies and the Role of Early Screening
Alipova G. Ablakimova N. Tussupkaliyeva K. Bermagambetova S. Kosmuratova S. Karimsakova B. Gaiday A. Gaiday A. Dinets A. Tussupkaliyev A.
May 2025Multidisciplinary Digital Publishing Institute (MDPI)
Journal of Clinical Medicine
2025#14Issue 9
Background: Pre-eclampsia (PE) remains a leading cause of maternal and perinatal morbidity and mortality worldwide. Early detection and risk stratification are critical for improving pregnancy outcomes. This review aims to summarize current advancements in PE screening, including clinical risk factors, biomarkers, imaging techniques, and predictive models. Methods: A comprehensive literature search was conducted using PubMed, Scopus, Web of Science, and Google Scholar to identify relevant studies on PE screening and prediction. Peer-reviewed original studies, systematic reviews, and meta-analyses published in English were included, while case reports and conference abstracts were excluded. Results: Traditional screening methods rely on maternal history and clinical risk factors, while emerging approaches incorporate biochemical markers and ultrasound parameters to enhance predictive accuracy. Machine learning models and artificial intelligence (AI)-driven algorithms are being explored for improved risk stratification. However, challenges such as data heterogeneity, lack of external validation, and integration into clinical practice remain. Conclusions: Advances in PE screening hold promise for early identification and targeted prevention strategies. Future research should focus on validating predictive models in diverse populations, integrating AI with traditional screening methods, and developing personalized approaches to reduce PE-associated complications.
biomarkers , early diagnosis , pre-eclampsia , prenatal screening , risk assessment
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Department of Obstetrics and Gynecology, West Kazakhstan Marat Ospanov Medical University, Aktobe, 030012, Kazakhstan
Department of Pharmacology, Clinical Pharmacology, West Kazakhstan Marat Ospanov Medical University, Aktobe, 030012, Kazakhstan
Department of Hospital Pharmacy, Regional Perinatal Center, Aktobe, 030006, Kazakhstan
Department of Epidemiology, West Kazakhstan Marat Ospanov Medical University, Aktobe, 030012, Kazakhstan
Department of Hygienic Disciplines and Occupational Diseases, West Kazakhstan Marat Ospanov Medical University, Aktobe, 030012, Kazakhstan
Department of Normal Physiology, Ospanov Medical University, West Kazakhstan Marat, Aktobe, 030012, Kazakhstan
Department of General Medical Practice №1, West Kazakhstan Marat Ospanov Medical University, Aktobe, 030012, Kazakhstan
Department of Radiology, West Kazakhstan Marat Ospanov Medical University, Aktobe, 030012, Kazakhstan
Institute of Biology and Medicine, Taras Shevchenko National University of Kiyv, Kyiv, 01033, Ukraine
Department of Obstetrics and Gynecology
Department of Pharmacology
Department of Hospital Pharmacy
Department of Epidemiology
Department of Hygienic Disciplines and Occupational Diseases
Department of Normal Physiology
Department of General Medical Practice №1
Department of Radiology
Institute of Biology and Medicine
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