Premenstrual Syndrome Clinical Manifestations Peculiarities in Adolescents

Alimbayeva G. Nurbayeva T.
2022 Professionalnye Izdaniya

Reproductive Health Eastern Europe
2022 #12 Issue 3 325 - 337 pp.

The prevalence and peculiarities of premenstrual syndrome in adolescence have not been studied enough. Methods of therapy for the syndrome in adolescents remain debatable. The purpose of the study. Investigation of the PMS clinical manifestations in adolescent girls and evaluation the effectiveness Prefemin (Agnus castus 20 mg) in relieving symptoms. Materials and methods. A prospective study of PMS symptoms in 31 girls aged 17-19 yo (18.2±0.8 years) before and during 3-month therapy with Prefemin (Agnus castus 20 mg). Menarche was 14.1±0.3 yo, gynecological age 4.1±1.3 years. BMI was 23.2±2.5 kg/m2. The research instrument was the Menstrual Distress Questionnaire (MDQ, 1969), which includes 47 PMS symptoms divided into 6 groups. Significant symptoms were determined with strength of 2-3 points, affecting the quality of life. The presence of the symptom and its severity were assessed by the participants themselves after the briefing. Preliminary assessment of symptoms was carried out retrospectively. Results. Initially, there were 13.1 symptoms of PMS for each girl, while psycho-emotional symptoms were 5.1; neurological - 2.7; water-electrolyte - 2.0; gastrointestinal - 2.7; skin 1.7 and musculoskeletal 3.5. Two girls indicated 26 and 21 symptoms. Psychoemotional symptoms were in 100% and were effectively stopped by Prefemin (71%), a similar effect in the group of water and electrolyte symptoms (71%). The group of musculoskeletal symptoms was initially the second in frequency (in 77.4%), but with a lesser effect of therapy (in 58.1%), the group of skin manifestations, which were noted by 17 girls (54.8%), on the positive effect of therapy indicated 8 girls or 1/2 of the original. Problems persisted regarding acne. Conclusion. Agnus castus at a dose of 20 mg per day for 3 months is effective in relieving most of the symptoms of PMS in adolescents aged 18-19 years and is a significant alternative to SSRIs. The la ck of effect within 3 months of PMS therapy is the basis for an additional examination and clarification of the diagnosis.

Adolescents , Agnus castus , PMDD , PMS

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Medical Center KRAS, Almaty, Kazakhstan
Asfendiyarov Kazakh National Medical University, Almaty, Kazakhstan

Medical Center KRAS
Asfendiyarov Kazakh National Medical University

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