An Update on Functionalized Graphene Nanosheets as an Electrochemical Nano-Biosensors for Breast Cancer Detection: A Review
Alekseevich A.G. Kalimoldina L. Nurushev M. Fazliddinovich N.R. Rustamkulovna S.T. Zokirova G. Khurramov E. Sapaev I.B. Kizi M.L.T. Sayfullaevna K.G. Abdullayeva G. Ugli M.S.S. Ugli E.U.S.
2024University of Kashan
Journal of Nanostructures
2024#14Issue 2608 - 621 pp.
This review presents an extensive examination of the progress made in the development of functionalized graphene nanosheets as electrochemical nano-biosensors for breast cancer detection. The distinctive characteristics of graphene, such as its substantial surface area and superior electrical conductivity, render it a highly suitable material for biosensing applications. Recent research has illustrated the efficacy of these biosensors in identifying specific biomarkers linked to breast cancer, including the BRCA1 gene and CA 15–3, demonstrating remarkable sensitivity and minimal detection limits. For example, a cutting-edge sensing platform that employs graphene oxide and ionic liquid composites has achieved a detection limit of 1.48 µg/mL for the BRCA1 gene, highlighting the potential of these materials in clinical diagnostics. Additionally, the review underscores the significance of optimizing sensor performance through various factors, such as ionic liquid concentration and hybridization time, to improve detection capabilities. Despite the encouraging findings, challenges persist regarding the reproducibility and stability of graphene materials, which call for further investigation to overcome these issues. The review also stresses the necessity for standardization in manufacturing processes and the investigation of additional biomarkers to expand the applicability of these biosensors. In summary, this manuscript highlights the transformative potential of functionalized graphene nanosheets in the early detection of breast cancer, setting the stage for future advancements in diagnostic technologies. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
Breast cancer , Detection , Functionalization , Graphene nanosheet , Nano-biosensor
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Department of Oncology, Asfendiyarov Kazakh National Medical University, Almaty, Kazakhstan
Department Chemistry, Faculty of Food Technologies, Chemical Technology and Ecology Almaty, Kazakhstan
High School of Natural Sciences, Astana International University, Astana, Kazakhstan
Institute of Immunology and Human Genomics, Academy of Sciences, Uzbekistan
Department of social science, Tashkent State University of Economics, Tashkent, Uzbekistan
Termez State University, Termez, Uzbekistan
Tashkent Institute of Irrigation and Agricultural Mechanization Engineers National Research University, Tashkent, Uzbekistan
University of Tashkent for Applied Sciences, Tashkent, Uzbekistan
Western Caspian University, Baku, Azerbaijan
Faculty of Philology of Uzbek and Russian language of the Kokand Pedagogical Institute, Uzbekistan
Department of Propaedeutics, Internal Medicine of the Bukhara State Medical Institute, Uzbekistan
Chirchik State Pedagogical University, Uzbekistan
Faculty of Foreign Languages of the Jizzakh State Pedagogical University, Uzbekistan
Department of Urology and Oncology, Fergana medical institute of Public health, Fergana, Uzbekistan
Department of Oncology
Department Chemistry
High School of Natural Sciences
Institute of Immunology and Human Genomics
Department of social science
Termez State University
Tashkent Institute of Irrigation and Agricultural Mechanization Engineers National Research University
University of Tashkent for Applied Sciences
Western Caspian University
Faculty of Philology of Uzbek and Russian language of the Kokand Pedagogical Institute
Department of Propaedeutics
Chirchik State Pedagogical University
Faculty of Foreign Languages of the Jizzakh State Pedagogical University
Department of Urology and Oncology
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