Synthesis of 3,5-bis(arylidene)piperidin-4-ones with a polyester chain as an approach to obtaining molecules with improved solubility
Aleksandrova Y.R. Neganova M.E. Shagina I.A. Kolesnikov A.S. Tapalova A.S. Brel V.K.
December 2025Springer
Russian Chemical Bulletin
2025#74Issue 123794 - 3801 pp.
In order to improve the solubility of 3,5-bis(arylidene)piperidin-4-ones with various substituents in the benzene ring, the corresponding 2-(2-methoxyethoxy)ethyl-[3,5-bis-(arylidene)-4-oxo-1-piperidinyl]acetates were obtained. Evaluation of their physicochemical characteristics in silico showed that the inclusion of 2-(2-methoxyethoxy)ethanol with an OMe terminal group in the piperidone molecules improves its pharmacokinetic characteristics and, as a consequence, its solubility in aqueous media and cytotoxic profile.
2-(2-methoxyethoxy)ethanol , 3,5-bis(arylidene)piperidin-4-ones , bioavailability , cytotoxicity , solubility
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A. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, 28/1 ul. Vavilova, Moscow, 119334, Russian Federation
Laboratory of Engineering Profile “Physical and Chemical Methods of Analysis”, Korkyt Ata Kyzylorda University, 29A ul. Aiteke bi, Kyzylorda, 120014, Kazakhstan
Institute of Physiologically Active Compounds, Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry Russian Academy of Sciences, 1 Severny proezd, Chernogolovka, Moscow Region, 142432, Russian Federation
Institute of Natural Science, Korkyt Ata Kyzylorda University, 29A ul. Aiteke bi, Kyzylorda, 120014, Kazakhstan
A. N. Nesmeyanov Institute of Organoelement Compounds
Laboratory of Engineering Profile “Physical and Chemical Methods of Analysis”
Institute of Physiologically Active Compounds
Institute of Natural Science
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