HSP70 and HSP90 in Cancer: Cytosolic, Endoplasmic Reticulum and Mitochondrial Chaperones of Tumorigenesis
Albakova Z. Mangasarova Y. Albakov A. Gorenkova L.
21 January 2022Frontiers Media S.A.
Frontiers in Oncology
2022#12
HSP70 and HSP90 are two powerful chaperone machineries involved in survival and proliferation of tumor cells. Residing in various cellular compartments, HSP70 and HSP90 perform specific functions. Concurrently, HSP70 and HSP90 homologs may also translocate from their primary site under various stress conditions. Herein, we address the current literature on the role of HSP70 and HSP90 chaperone networks in cancer. The goal is to provide a comprehensive review on the functions of cytosolic, mitochondrial and endoplasmic reticulum HSP70 and HSP90 homologs in cancer. Given that high expression of HSP70 and HSP90 enhances tumor development and associates with tumor aggressiveness, further understanding of HSP70 and HSP90 chaperone networks may provide clues for the discoveries of novel anti-cancer therapies. Copyright
cancer , GRP78 , GRP94 , heat shock proteins , HSP70 , HSP90 , mortalin , TRAP1
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Department of Biology, Lomonosov Moscow State University, Moscow, Russian Federation
National Research Center for Hematology, Moscow, Russian Federation
Department of Innovation, Almaty, Kazakhstan
Department of Biology
National Research Center for Hematology
Department of Innovation
10 лет помогаем публиковать статьи Международный издатель
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