The Effects of Bovine Colostrum on the Stress-Hyperglycemia Ratio and the Triglyceride-Glucose Index in Exercise-Trained Healthy Subjects: A Double-Blind, Placebo-Controlled Clinical Study
Al-Nimer M.S. Al-Basri A.K. Satmbekova D. Datkhayev U.M.
2023University of Baghdad - College of Pharmacy
Iraqi Journal of Pharmaceutical Sciences
2023#32104 - 109 pp.
Bovine colostrum (BC) is a natural substance that has been shown of benefits for exercising, and reducing the blood glucose levels in type 2 diabetes. Stress hyperglycemia is a brief rise in blood glucose levels caused by physiological stress. This placebo-controlled clinical study aimed to investigate the effects of BC on stress hyperglycemia and the triglyceride-glucose index in healthy subjects who trained in resistance exercise. This research was carried out at Al-Kut University College from April 30th to November 30th, 2022. Fifty healthy young men were randomly assigned: Group I (n = 24) received a placebo, whereas Group II (n = 26) received a 500mg single oral dosage of BC nutraceutical pill. During the treatment period, both groups of volunteers engaged in resistance exercise training. Body mass index (BMI), waist circumference (WC), stress glucose ratio (SGR), triglyceride-glucose index (TyGI), and rate pressure product (as a hemodynamic response) were all measured at the start and end of the eight-week study. Stress blood glucose levels were considerably higher in Group II following resistance training (89.0±6.5 vs 102.1±11.5mg/dL, p<0.001), whereas stress HbA1c% did not alter (4.70±0.25 vs 4.66±0.29, p=0.608). Bovine colostrum significantly increases the SGR from 1.01±0.03 to 1.18±0.13, p<0.001. The TyGI at the stress glucose level was increased by 2.7%. We conclude that bovine colostrum significantly elevates the stress hyperglycemic ratio without inducing significant changes in the TyGI following exercise. This impact is accompanied by a stabilizing hemodynamic response.
Bovine colostrum , Rate pressure product , Stress glucose level , Triglyceride-glucose index
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College of Medicine, University of Diyala, Baqubah, 32001, Iraq
Department of Pharmacy, Al-Kut University College, Wasit, 52001, Iraq
Al-Farabi Kazakh National University, Almaty, Kazakhstan
Asfendiyarov Kazakh National Medical University, Almaty, Kazakhstan
College of Medicine
Department of Pharmacy
Al-Farabi Kazakh National University
Asfendiyarov Kazakh National Medical University
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