Nigella sativa L. as a Potential Natural Product for the Treatment of COVID-19
Al Azzam K.M. Al Omari R.H. Aboalroub A. Bekbayeva L. Negim E.-S. Aboul-Enein H.Y.
October 2022NIDOC (Nat.Inform.Document.Centre)
Egyptian Journal of Chemistry
2022#65Issue 10141 - 151 pp.
The world is now facing a public health emergency caused by the coronavirus pandemic (COVID-19). The World Health Organization (WHO) has called it an emerging pandemic due to its sudden appearance and distribution. Coronavirus disease 2019 (COVID-19) is a pandemic caused by the Coronavirus2 of the Extreme Acute Respiratory Syndrome (SARS-CoV2). Nigella sativa (N. sativa) (Family Ranunculaceae) is a globally used medicinal herb. Unani and Tibb, Ayurveda, and Siddha are only a few of the western medical systems that use it. N. sativa, also known as black seed, is an essential medicinal plant that has long been used as a multipurpose medicinal agent in various countries. Immune deficiency, autophagy deficiency, oxidative stress, pathological inflammation, diabetes, cardiovascular diseases, and bacterial and viral infections are all treated effectively with the essential oil and other preparations of the N. sativa crop. It comprises of many essential groups of bioactive compounds, one of which, thymoquinone, has piqued the scientific communitys interest due to its active function in treating a wide variety of diseases. The therapeutic effectiveness of N. sativa, as well as recent computational results, clearly suggest that it may be used to tackle the COVID-19 pandemic that has recently arisen. The aim of this review is to highlight the therapeutic importance of N. sativa in conventional medicine, as well as the potential for its use as an antiviral agent against the SARSCoV2 virus and for further preclinical research.
COVID-19 , natural products , Nigella sativa , pandemic , SARS-CoV2 , World Health Organization
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Pharmacological and Diagnostic Research Center (PDRC), Department of Pharmaceutical Sciences, Faculty of Pharmacy, Al-Ahliyya Amman University, Amman, 19328, Jordan
S.D. Asfendiyarov Kazakh National Medical University, Department of Biochemistry, 88 Tole bi St., Almaty, Kazakhstan
Laboratory of Advanced Materials and Technology, Kazakh-British Technical University, 59 Tole bi St., Almaty, 050000, Kazakhstan
Department of Pharmaceutical and Medicinal Chemistry, Pharmaceutical and Drug Industries Research Division, National Research Center, Giza, Dokki, Egypt
Pharmacological and Diagnostic Research Center (PDRC)
S.D. Asfendiyarov Kazakh National Medical University
Laboratory of Advanced Materials and Technology
Department of Pharmaceutical and Medicinal Chemistry
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