Pathological role of LncRNAs in immune-related disease via regulation of T regulatory cells
Al-Hawary S.I.S. Kashikova K. Ioffe E.M. Izbasarova A. Hjazi A. Tayyib N.A. Alsalamy A. Hussien B.M. Hameed M. abdalkareem M.J.
September 2023Elsevier GmbH
Pathology Research and Practice
2023#249
Human regulatory T cells (Tregs) are essential in pathogenesis of several diseases such as autoimmune diseases and cancers, and their imbalances may be promoting factor in these disorders. The development of the proinflammatory T cell subset TH17 and its balance with the generation of regulatory T cells (Treg) is linked to autoimmune disease and cancers. Long non-coding RNAs (lncRNAs) have recently emerged as powerful regulatory molecules in a variety of diseases and can regulate the expression of significant genes at multiple levels through epigenetic regulation and by modulating transcription, post-transcriptional processes, translation, and protein modification. They may interact with a wide range of molecules, including DNA, RNA, and proteins, and have a complex structural makeup. LncRNAs are implicated in a range of illnesses due to their regulatory impact on a variety of biological processes such as cell proliferation, apoptosis, and differentiation. In this regard, a prominent example is lncRNA NEAT1 which several studies have performed to determine its role in the differentiation of immune cells. Many other lncRNAs have been linked to Treg cell differentiation in the context of immune cell differentiation. In this study, we review recent research on the various roles of lncRNAs in differentiation of Treg cell and regulation of the Th17/Treg balance in autoimmune diseases and tumors in which T regs play an important role.
Autoimmune diseases , Differentiation , Long-non-coding RNA , T regulatory cells
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Department of Business Administration, Business School, Al al-Bayt University, P.O.BOX 130040, Mafraq, 25113, Jordan
Caspian University, International School of Medicine, Almaty, Kazakhstan
Department of Military Clinical Hospital, Ministry of Defence, Almaty, Kazakhstan
“KazNMU named S.D. Asfendiyarov”, Almaty, Kazakhstan
Department of Medical Laboratory Sciences, College of Applied Medical Sciences, Prince Sattam bin Abdulaziz University, Al-Kharj, 11942, Saudi Arabia
Faculty of Nursing, Umm Al-Qura University, Makkah, Saudi Arabia
College of technical engineering, Imam Jaafar Al-Sadiq University, Al-Muthanna, 66002, Iraq
Medical Laboratory Technology Department, College of Medical Technology, The Islamic University, Najaf, Iraq
Medical Technical College, Al-Farahidi University, Baghdad, Iraq
Department of Medical Laboratory Technologies, Al Rafidain University College, Bagdad, Iraq
Department of Business Administration
Caspian University
Department of Military Clinical Hospital
“KazNMU named S.D. Asfendiyarov”
Department of Medical Laboratory Sciences
Faculty of Nursing
College of technical engineering
Medical Laboratory Technology Department
Medical Technical College
Department of Medical Laboratory Technologies
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