Safety and Immunogenic Efficacy of Inactivated Monovalent Vaccines against Newcastle Disease in the Republic of Kazakhstan
Akmyrzayev N.Z. Assanzhanova N.N. Kydyrbayev Z. Ryskeldinova S. Zhunushov A.T. Kozhamkulov Y. Mailybayeva A.M. Sagymbayeva A.M. Myrzakhmetov Y.
April 2025Springer
Bulletin of Experimental Biology and Medicine
2025#178Issue 6739 - 743 pp.
The effectiveness of the inactivated vaccines developed by us against the Newcastle disease virus was studied in chickens after infection with a highly virulent Alatau-98 strain. The vaccines in the form of a stable water-oil emulsion were prepared using Montanide ISA 70 VG adjuvant. The immunogenicity of the vaccines was checked 7, 14, 21, and 28 days after administration. The effectiveness was determined by the ability of the vaccine preparations to protect against the disease and by mortality after infection with a highly virulent Alatau-98 strain. Inactivated vaccines developed by us have shown promising results in protecting birds from Newcastle disease and can significantly improve disease control in domestic poultry.
efficacy , harmlessness , immunogenicity , inactivated vaccine , Newcastle’s disease
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Research Institute for Biological Safety Problems, Gvardeysky, Kazakhstan
Institute of Biotechnology, National Academy of Sciences of the Kyrgyz Republic, Bishkek, Kyrgyzstan
Research Institute for Biological Safety Problems
Institute of Biotechnology
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