The role of SHBG and LPL gene polymorphism in the development of age-related hypogonadism in overweight men: Literature review
Akkaliyev M. Aukenov N. Massabayeva M. Apsalikov B. Rakhyzhanova S. Kuderbaev M.
2021National Scientific Medical Center
Journal of Clinical Medicine of Kazakhstan
2021#18Issue 511 - 17 pp.
Testosterone is the main male hormone responsible for the formation and maintenance of male sex characteristics and the sexual performance of men. With age testosterone levels decrease which is a natural physiological process. But the timing of age-related hypogonadism progress has individual differences. Physiological processes occurring in the body of an aging man are due to genetic, population and individual features of genes and their mutations leading to genetic polymorphism. Gene polymorphism is represented mainly by single nucleotide substitutions that are SNP (single nucleotide polymorphism). Sex hormone binding globulin (SHBG) and lipoprotein lipase (LPL) genes are important links in the synthesis and transport of testosterone in male body as well as in the development of androgen deficiency. This review discusses the role of polymorphic variants of SHBG and LPL genes in the early development of age-related hypogonadism in overweight men.
age-related hypogonadism in men , erectile dysfunction , obesity , overweight , polymorphism of SHBG and LPL genes
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Department of Surgery Disciplines, Semey Medical University, Semey, Kazakhstan
Department of Health and Human Resources, Ministry of Healthcare of the Republic of Kazakhstan, Semey, Kazakhstan
Scientific-Research Laboratory Center, Semey Medical University, Semey, Kazakhstan
Department of Family Medicine, Semey Medical University, Semey, Kazakhstan
Department of Normal Physiology, Semey Medical University, Semey, Kazakhstan
Department of Surgery Disciplines
Department of Health and Human Resources
Scientific-Research Laboratory Center
Department of Family Medicine
Department of Normal Physiology
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