Therapeutic potential of resveratrol and autologous chondrocytes in male rat knee joint cartilage repair
Akhlagh A. Iraji A. Daneshi S.S. Kian M. Jamshidzadeh A. Zare S. Tanideh N. Naseh M. Mussin N.M. Kurmanalina M.A. Tamadon A.
2026Taylor and Francis Ltd.
Natural Product Research
2026#40Issue 61406 - 1420 pp.
Osteochondral defects (OCDs) in synovial joints are caused by trauma or inflammatory joint diseases, with no definitive treatment available. This study examined the effects of resveratrol and chondrocyte injections in a rat model of OCD. Twenty-four male Sprague-Dawley rats were divided into four groups: a control group, a resveratrol-only group (10 mg/kg), a chondrocyte-only group (1 × 105 cells), and a combined treatment group that received both treatments. After two months, the rats were euthanized, and their knee joints were analysed histologically and immunohistochemically. The results showed that the combined resveratrol and chondrocyte treatment significantly reduced fibrous tissue, increased cartilage tissue volume, improved cellular distribution, and enhanced the regularity of the articular surface. Collagen types I and II and proteoglycan levels were also elevated. These findings suggest that the combination of resveratrol and chondrocytes has a synergistic effect, promoting effective OCD repair in this rat model, offering potential for future therapeutic approaches.
chondrocytes , knee joint , Osteochondral defects , rats , resveratrol
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Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran
Stem Cells Technology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
Department of Comparative Biomedical Sciences, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Iran
Department of Pharmacology-Toxicology, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran
Department of Pharmacology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
PerciaVista R&D Co, Shiraz, Iran
Histomorphometry and Stereology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
Department of Surgery No. 2, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan
Department of Therapeutic and Prosthetic Dentistry, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan
Department of Natural Sciences, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan
Student Research Committee
Stem Cells Technology Research Center
Department of Comparative Biomedical Sciences
Department of Pharmacology-Toxicology
Department of Pharmacology
PerciaVista R&D Co
Histomorphometry and Stereology Research Center
Department of Surgery No. 2
Department of Therapeutic and Prosthetic Dentistry
Department of Natural Sciences
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